| Literature DB >> 15503355 |
Jussara Pinheiro Barbosa1, Renato Crespo Pereira, Juliana Lourenço Abrantes, Cláudio César Cirne dos Santos, Moacyr Alcoforado Rebello, Izabel Christina de Palmer Paixão Frugulhetti, Valéria Laneuville Texeira.
Abstract
Specimens of Dictyota pfaffii from Atol das Rocas, Northeast Brazil, afforded the rare dolabellane diterpene 10,18-diacetoxy-8-hydroxy-2, 6-dolabelladiene (1) and the new 10-acetoxy-8,18-di-hydroxy-2,6-dolabelladiene (2). Reduction of 1 yielded 8,10,18-trihydroxy-2,6-dolabelladiene (3), also present in the crude ex-tract of D. pfaffii. All three structures were assigned by 1D and 2D NMR spectral data. These substances showed strong anti-HSV-1 activity in vitro but only 3 inhibited the reverse transcriptase enzyme of HIV-1.Entities:
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Year: 2004 PMID： 15503355 DOI： 10.1055/s-2004-827235
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352