OBJECTIVE: To analyse the topography of cerebral microbleeds (CMBs) visualized by T2*-weighted gradient-echo MR imaging in the supratentorial brain area, based on the anatomical classification of the regions and the arterial territories. BACKGROUND: CMBs are associated with hypertension and the risk of intracerebral hemorrhage; however, little is known about the cerebral topography of CMBs. METHODS: We examined 164 consecutive patients with hypertensive stroke who underwent T2*-weighted gradient-echo MRI. The anatomical locations and the vascular territories of the CMBs were determined in the subcortical white matter, basal ganglia/internal capsule and thalamus along the standard axial slices. RESULTS: We detected 2,193 CMBs in 98 patients (13.4+/-39.0 per patient). The CMBs showed a significant predilection for the temporo-occipital area of the subcortical white matter, the posterolateral part of the upper putamen, and the lateral nuclei of the mid-level thalamus. The most common arterial territories were those of the middle-posterior cerebral artery in the white matter, the middle cerebral artery in the basal ganglia, and the thalamogeniculate artery in the thalamus. CONCLUSIONS: These findings were quite similar to the cerebral topography of intracerebral hemorrhage described in the literature. Our results suggest that CMBs are regionally associated with intracerebral hemorrhage.
OBJECTIVE: To analyse the topography of cerebral microbleeds (CMBs) visualized by T2*-weighted gradient-echo MR imaging in the supratentorial brain area, based on the anatomical classification of the regions and the arterial territories. BACKGROUND:CMBs are associated with hypertension and the risk of intracerebral hemorrhage; however, little is known about the cerebral topography of CMBs. METHODS: We examined 164 consecutive patients with hypertensive stroke who underwent T2*-weighted gradient-echo MRI. The anatomical locations and the vascular territories of the CMBs were determined in the subcortical white matter, basal ganglia/internal capsule and thalamus along the standard axial slices. RESULTS: We detected 2,193 CMBs in 98 patients (13.4+/-39.0 per patient). The CMBs showed a significant predilection for the temporo-occipital area of the subcortical white matter, the posterolateral part of the upper putamen, and the lateral nuclei of the mid-level thalamus. The most common arterial territories were those of the middle-posterior cerebral artery in the white matter, the middle cerebral artery in the basal ganglia, and the thalamogeniculate artery in the thalamus. CONCLUSIONS: These findings were quite similar to the cerebral topography of intracerebral hemorrhage described in the literature. Our results suggest that CMBs are regionally associated with intracerebral hemorrhage.
Authors: Omar M Al-Janabi; Christopher A Brown; Ahmed A Bahrani; Erin L Abner; Justin M Barber; Brian T Gold; Larry B Goldstein; Ronan R Murphy; Peter T Nelson; Nathan F Johnson; Leslie M Shaw; Charles D Smith; John Q Trojanowski; Donna M Wilcock; Gregory A Jicha Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: Y Sueda; H Naka; T Ohtsuki; T Kono; S Aoki; T Ohshita; E Nomura; S Wakabayashi; T Kohriyama; M Matsumoto Journal: AJNR Am J Neuroradiol Date: 2010-05-06 Impact factor: 3.825
Authors: Eric E Smith; Kaveer R N Nandigam; Yu-Wei Chen; Jed Jeng; David Salat; Amy Halpin; Matthew Frosch; Lauren Wendell; Louis Fazen; Jonathan Rosand; Anand Viswanathan; Steven M Greenberg Journal: Stroke Date: 2010-08-05 Impact factor: 7.914
Authors: Yannie O Y Soo; Song Ran Yang; Wynnie W M Lam; Adrian Wong; Yu Hua Fan; Howan H W Leung; Anne Y Y Chan; Cecilia Leung; Thomas W H Leung; Lawrence K S Wong Journal: J Neurol Date: 2008-12-08 Impact factor: 4.849