PURPOSE OF REVIEW: Pulmonary arterial hypertension (PAH) is defined as a group of diseases characterized by a progressive increase of pulmonary vascular resistance leading to right ventricular failure and premature death. The purpose of this review is to analyze the current knowledge of the evaluation of PAH patients. RECENT FINDINGS: Recently, the diagnostic approach has been more clearly defined according to the new clinical classification and with consensus reached on algorithms of various investigative tests and procedures that exclude other causes and ensure an accurate diagnosis of PAH. The diagnostic procedures include clinical history and physical examination, ECG, chest radiography, transthoracic Doppler echocardiography, pulmonary function tests, arterial blood gases, ventilation and perfusion lung scan, high-resolution CT of the lung, contrast-enhanced spiral CT of the lung and pulmonary angiography, blood tests and immunology, abdominal ultrasound scan, exercise capacity assessment, and hemodynamic evaluation. SUMMARY: Invasive and noninvasive markers of disease severity, either biomarkers or physiologic parameters and tests that can be widely applied, have been proposed to reliably diagnose PAH and monitor the clinical course.
PURPOSE OF REVIEW: Pulmonary arterial hypertension (PAH) is defined as a group of diseases characterized by a progressive increase of pulmonary vascular resistance leading to right ventricular failure and premature death. The purpose of this review is to analyze the current knowledge of the evaluation of PAH patients. RECENT FINDINGS: Recently, the diagnostic approach has been more clearly defined according to the new clinical classification and with consensus reached on algorithms of various investigative tests and procedures that exclude other causes and ensure an accurate diagnosis of PAH. The diagnostic procedures include clinical history and physical examination, ECG, chest radiography, transthoracic Doppler echocardiography, pulmonary function tests, arterial blood gases, ventilation and perfusion lung scan, high-resolution CT of the lung, contrast-enhanced spiral CT of the lung and pulmonary angiography, blood tests and immunology, abdominal ultrasound scan, exercise capacity assessment, and hemodynamic evaluation. SUMMARY: Invasive and noninvasive markers of disease severity, either biomarkers or physiologic parameters and tests that can be widely applied, have been proposed to reliably diagnose PAH and monitor the clinical course.
Authors: Quynh A Truong; Joseph M Massaro; Ian S Rogers; Amir A Mahabadi; Matthias F Kriegel; Caroline S Fox; Christopher J O'Donnell; Udo Hoffmann Journal: Circ Cardiovasc Imaging Date: 2011-12-16 Impact factor: 7.792
Authors: Madhukar B Kolli; Nandini D P K Manne; Radhakrishna Para; Siva K Nalabotu; Geeta Nandyala; Tolou Shokuhfar; Kun He; Azhang Hamlekhan; Jane Y Ma; Paulette S Wehner; Lucy Dornon; Ravikumar Arvapalli; Kevin M Rice; Eric R Blough Journal: Biomaterials Date: 2014-09-15 Impact factor: 12.479
Authors: Nathalie van der Velde; Bruno H Ch Stricker; Jos R T C Roelandt; Folkert J Ten Cate; Tischa J M van der Cammen Journal: PLoS One Date: 2007-07-25 Impact factor: 3.240