Literature DB >> 15502365

Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes.

Hajime Motoyoshi1, Masato Horigome, Ken Ishigami, Tatsuhiko Yoshida, Sueharu Horinouchi, Minoru Yoshida, Hidenori Watanabe, Takeshi Kitahara.   

Abstract

The structure-activity relationship for FR901464, a potent cell-cycle inhibitor, was examined by synthesizing its analogs. A versatile method for converting FR901464 was devised. This method made it possible to synthesize biologically active FR901464-biotin conjugates which could be used to isolate the binding proteins.

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Year:  2004        PMID： 15502365     DOI： 10.1271/bbb.68.2178

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  23 in total

1.  Total syntheses, fragmentation studies, and antitumor/antiproliferative activities of FR901464 and its low picomolar analogue.

Authors:  Brian J Albert; Ananthapadmanabhan Sivaramakrishnan; Tadaatsu Naka; Nancy L Czaicki; Kazunori Koide
Journal:  J Am Chem Soc       Date:  2007-02-06       Impact factor: 15.419

2.  Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

Authors:  Chandraiah Lagisetti; Alan Pourpak; Tinopiwa Goronga; Qin Jiang; Xiaoli Cui; Judith Hyle; Jill M Lahti; Stephan W Morris; Thomas R Webb
Journal:  J Med Chem       Date:  2009-11-26       Impact factor: 7.446

3.  Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464.

Authors:  Sami Osman; Brian J Albert; Yanping Wang; Miaosheng Li; Nancy L Czaicki; Kazunori Koide
Journal:  Chemistry       Date:  2010-11-19       Impact factor: 5.236

4.  Isolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp. No. 2663.

Authors:  Xiangyang Liu; Sreya Biswas; Gong-Li Tang; Yi-Qiang Cheng
Journal:  J Antibiot (Tokyo)       Date:  2013-05-08       Impact factor: 2.649

5.  Achmatowicz Reaction and its Application in the Syntheses of Bioactive Molecules.

Authors:  Arun K Ghosh; Margherita Brindisi
Journal:  RSC Adv       Date:  2016-11-24       Impact factor: 3.361

6.  Enantioselective syntheses of FR901464 and spliceostatin A: potent inhibitors of spliceosome.

Authors:  Arun K Ghosh; Zhi-Hua Chen
Journal:  Org Lett       Date:  2013-09-19       Impact factor: 6.005

7.  Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate-dependent dioxygenase.

Authors:  Alessandra S Eustáquio; Jeffrey E Janso; Anokha S Ratnayake; Christopher J O'Donnell; Frank E Koehn
Journal:  Proc Natl Acad Sci U S A       Date:  2014-08-05       Impact factor: 11.205

Review 8.  Modulating splicing with small molecular inhibitors of the spliceosome.

Authors:  Kerstin A Effenberger; Veronica K Urabe; Melissa S Jurica
Journal:  Wiley Interdiscip Rev RNA       Date:  2016-07-21       Impact factor: 9.957

9.  Antitumor compounds based on a natural product consensus pharmacophore.

Authors:  Chandraiah Lagisetti; Alan Pourpak; Qin Jiang; Xiaoli Cui; Tinopiwa Goronga; Stephan W Morris; Thomas R Webb
Journal:  J Med Chem       Date:  2008-09-13       Impact factor: 7.446

Review 10.  The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.

Authors:  Thomas R Webb; Amanda S Joyner; Philip M Potter
Journal:  Drug Discov Today       Date:  2012-08-03       Impact factor: 7.851
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