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Literature DB >> 15501812

Interleukin-15-deficient mice develop protective immunity to Toxoplasma gondii.

Linda A Lieberman¹, Eric N Villegas, Christopher A Hunter.

Abstract

Previous studies have suggested an important role for interleukin-15 (IL-15) in resistance to and memory for Toxoplasma gondii infection. The studies presented here reveal that IL-15 is not required for infection-induced expansion of NK or CD8+ T cells. Furthermore, IL-15-/- mice develop long-term protective immunity to this pathogen.

Entities: Disease Gene Species

Mesh：

Substances：
Interleukin-15

Year: 2004 PMID： 15501812 PMCID： PMC523054 DOI： 10.1128/IAI.72.11.6729-6732.2004

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

18 in total

1. IL-15 prolongs the duration of CD8+ T cell-mediated immunity in mice infected with a vaccine strain of Toxoplasma gondii.

Authors: I A Khan; L Casciotti
Journal: J Immunol Date: 1999-10-15 Impact factor: 5.422

2. Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15Ralpha.

Authors: E John Wherry; Todd C Becker; David Boone; Murali-Krishna Kaja; Averil Ma; Rafi Ahmed
Journal: Adv Exp Med Biol Date: 2002 Impact factor: 2.622

3. IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells.

Authors: Mari Strengell; Sampsa Matikainen; Jukka Sirén; Anne Lehtonen; Don Foster; Ilkka Julkunen; Timo Sareneva
Journal: J Immunol Date: 2003-06-01 Impact factor: 5.422

4. Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine.

Authors: R T Gazzinelli; F T Hakim; S Hieny; G M Shearer; A Sher
Journal: J Immunol Date: 1991-01-01 Impact factor: 5.422

5. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.

Authors: Marion T Kasaian; Matthew J Whitters; Laura L Carter; Leslie D Lowe; Jason M Jussif; Bijia Deng; Kaley A Johnson; JoAnn S Witek; Mayra Senices; Richard F Konz; Andrea L Wurster; Debra D Donaldson; Mary Collins; Deborah A Young; Michael J Grusby
Journal: Immunity Date: 2002-04 Impact factor: 31.745

6. IL-21 induces the functional maturation of murine NK cells.

Authors: Jason Brady; Yoshihiro Hayakawa; Mark J Smyth; Stephen L Nutt
Journal: J Immunol Date: 2004-02-15 Impact factor: 5.422

7. Treatment with soluble interleukin-15Ralpha exacerbates intracellular parasitic infection by blocking the development of memory CD8+ T cell response.

Authors: Imtiaz A Khan; Magali Moretto; Xiao-Qing Wei; Martha Williams; Joseph D Schwartzman; Foo Y Liew
Journal: J Exp Med Date: 2002-06-03 Impact factor: 14.307

8. Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells.

Authors: Andrea L Wurster; Vikki L Rodgers; Abhay R Satoskar; Matthew J Whitters; Deborah A Young; Mary Collins; Michael J Grusby
Journal: J Exp Med Date: 2002-10-07 Impact factor: 14.307

10. Long-term immunity to lethal acute or chronic type II Toxoplasma gondii infection is effectively induced in genetically susceptible C57BL/6 mice by immunization with an attenuated type I vaccine strain.

Authors: Jason P Gigley; Barbara A Fox; David J Bzik
Journal: Infect Immun Date: 2009-09-21 Impact factor: 3.441

Interleukin-15-deficient mice develop protective immunity to Toxoplasma gondii.

1. IL-15 prolongs the duration of CD8+ T cell-mediated immunity in mice infected with a vaccine strain of Toxoplasma gondii.

2. Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15Ralpha.

3. IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells.

4. Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine.

5. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.

6. IL-21 induces the functional maturation of murine NK cells.

7. Treatment with soluble interleukin-15Ralpha exacerbates intracellular parasitic infection by blocking the development of memory CD8+ T cell response.

8. Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells.

9. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice.

10. Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells.

1. Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite.

Review 2. The immunology of parasite infections in immunocompromised hosts.

Review 3. Characteristics and critical function of CD8+ T cells in the Toxoplasma-infected brain.

Review 4. The CD8 T-cell road to immunotherapy of toxoplasmosis.

Review 5. CD8+ T cell immunity in an encephalitis model of Toxoplasma gondii infection.

6. Gamma interferon suppresses erythropoiesis via interleukin-15.

7. Flt3 Ligand Is Essential for Survival and Protective Immune Responses during Toxoplasmosis.

8. The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria.

Review 9. The role of IL-12 in stimulating NK cells against Toxoplasma gondii infection: a mini-review.

10. Long-term immunity to lethal acute or chronic type II Toxoplasma gondii infection is effectively induced in genetically susceptible C57BL/6 mice by immunization with an attenuated type I vaccine strain.