Literature DB >> 15501720

Stapled peptide induces cancer cell death.

Jo Whelan.   

Abstract

Hydrocarbon stapling could enable peptides from the key domains of natural proteins to be used therapeutically. Using the technique on a peptide involved in apoptosis, researchers have succeeded in destroying cancer cells in a mouse model of leukaemia.

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Year:  2004        PMID： 15501720     DOI： 10.1016/S1359-6446(04)03268-4

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  5 in total

1.  Bridged beta(3)-peptide inhibitors of p53-hDM2 complexation: correlation between affinity and cell permeability.

Authors:  Arjel D Bautista; Jacob S Appelbaum; Cody J Craig; Julien Michel; Alanna Schepartz
Journal:  J Am Chem Soc       Date:  2010-03-10       Impact factor: 15.419

2.  Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors.

Authors:  Randall J Platt; Tiffany S Han; Brad R Green; Misty D Smith; Jack Skalicky; Pawel Gruszczynski; H Steve White; Baldomero Olivera; Grzegorz Bulaj; Joanna Gajewiak
Journal:  J Biol Chem       Date:  2012-04-19       Impact factor: 5.157

3.  Novel structures of self-associating stapled peptides.

Authors:  Shibani Bhattacharya; Hongtao Zhang; David Cowburn; Asim K Debnath
Journal:  Biopolymers       Date:  2011-12-14       Impact factor: 2.505

4.  Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors.

Authors:  Ya-Qiu Long; Shao-Xu Huang; Zahrah Zawahir; Zhong-Liang Xu; Huiyuan Li; Tino W Sanchez; Ying Zhi; Stephanie De Houwer; Frauke Christ; Zeger Debyser; Nouri Neamati
Journal:  J Med Chem       Date:  2013-06-24       Impact factor: 7.446

Review 5.  Hydrocarbon-stapled peptides: principles, practice, and progress.

Authors:  Loren D Walensky; Gregory H Bird
Journal:  J Med Chem       Date:  2014-03-06       Impact factor: 7.446
  5 in total

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