| Literature DB >> 15501536 |
D L Hay1, A C Conner, S G Howitt, M A Takhshid, J Simms, K Mahmoud, D R Poyner.
Abstract
Historically, CGRP receptors have been classified as CGRP(1) or CGRP(2) subtypes, chiefly depending on their affinity for the antagonist CGRP(8-37). It has been shown that the complex between calcitonin receptor-like receptor (CRLR or CL) and receptor activity modifying protein (RAMP) 1 provides a molecular correlate for the CGRP(1) receptor; however, this does not explain the range of affinities seen for CGRP(8-37) in isolated tissues. It is suggested that these may largely be explained by a combination of methodological factors and CGRP-responsive receptors generated by CL and RAMP2 or RAMP3 and complexes of RAMPs with the calcitonin receptor.Entities:
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Year: 2004 PMID： 15501536 DOI： 10.1016/j.peptides.2004.06.007
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750