Literature DB >> 15501534

Adrenomedullin receptors: pharmacological features and possible pathophysiological roles.

Kenji Kuwasako1, Yuan-Ning Cao, Yasuko Nagoshi, Kazuo Kitamura, Tanenao Eto.   

Abstract

Three receptor activity modifying proteins (RAMPs) chaperone calcitonin-like receptor (CLR) to the cell surface. RAMP2 enables CLR to form an adrenomedullin (AM)-specific receptor that is sensitive to AM-(22-52) (AM(1) receptor). RAMP3 enables CLR to form an AM receptor sensitive to both calcitonin gene-related peptide (CGRP)-(8-37) and AM-(22-52) (AM(2) receptor), though rat and mouse AM(2) receptors show a clear preference for CGRP alpha-(8-37) over AM-(22-52). RAMP1 enables CRL to form the CGRP-(8-37)-sensitive CGRP(1) receptor, which can also be activated by higher concentrations of AM. Here we review the available information on the pharmacological features and possible pathophysiological roles of the aforementioned AM receptors.

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Year:  2004        PMID： 15501534     DOI： 10.1016/j.peptides.2004.06.002

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  10 in total

1.  The third extracellular loop of the human calcitonin receptor-like receptor is crucial for the activation of adrenomedullin signalling.

Authors:  Kenji Kuwasako; Debbie L Hay; Sayaka Nagata; Tomomi Hikosaka; Kazuo Kitamura; Johji Kato
Journal:  Br J Pharmacol       Date:  2012-05       Impact factor: 8.739

2.  The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity.

Authors:  Yuka Ichikawa-Shindo; Takayuki Sakurai; Akiko Kamiyoshi; Hisaka Kawate; Nobuyoshi Iinuma; Takahiro Yoshizawa; Teruhide Koyama; Junichi Fukuchi; Satoshi Iimuro; Nobuo Moriyama; Hayato Kawakami; Toshinori Murata; Kenji Kangawa; Ryozo Nagai; Takayuki Shindo
Journal:  J Clin Invest       Date:  2008-01       Impact factor: 14.808

Review 3.  Structure-function relationships of the N-terminus of receptor activity-modifying proteins.

Authors:  Tao Qi; Debbie L Hay
Journal:  Br J Pharmacol       Date:  2009-12-10       Impact factor: 8.739

4.  Lipopolysaccharide induces calcitonin gene-related peptide in the RAW264.7 macrophage cell line.

Authors:  Weiya Ma; Yvan Dumont; Freya Vercauteren; Remi Quirion
Journal:  Immunology       Date:  2010-02-05       Impact factor: 7.397

5.  Non-peptide small molecule regulators of lymphangiogenesis.

Authors:  Changge Fang; Marta Aparicio Miguel; Ingalill Avis; Alfredo Martinez; Enrique Zudaire; Frank Cuttitta
Journal:  Lymphat Res Biol       Date:  2009-12       Impact factor: 2.589

6.  Anti-inflammatory actions of adrenomedullin through fine tuning of HIF stabilization.

Authors:  Christopher F MacManus; Eric L Campbell; Simon Keely; Adrianne Burgess; Douglas J Kominsky; Sean P Colgan
Journal:  FASEB J       Date:  2011-02-24       Impact factor: 5.191

7.  Characterization and effects on cAMP accumulation of adrenomedullin and calcitonin gene-related peptide (CGRP) receptors in dissociated rat spinal cord cell culture.

Authors:  Mohammad A Takhshid; David R Poyner; Jean-Guy Chabot; Alain Fournier; Weiya Ma; Wen-Hua Zheng; Ali A Owji; Remi Quirion
Journal:  Br J Pharmacol       Date:  2006-05-15       Impact factor: 8.739

8.  Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males.

Authors:  Kathleen Caron; John Hagaman; Toshio Nishikimi; Hyung-Suk Kim; Oliver Smithies
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-20       Impact factor: 11.205

9.  Evidence for Conservation of the Calcitonin Superfamily and Activity-regulating Mechanisms in the Basal Chordate Branchiostoma floridae: INSIGHTS INTO THE MOLECULAR AND FUNCTIONAL EVOLUTION IN CHORDATES.

Authors:  Toshio Sekiguchi; Kenji Kuwasako; Michio Ogasawara; Hiroki Takahashi; Shin Matsubara; Tomohiro Osugi; Ikunobu Muramatsu; Yuichi Sasayama; Nobuo Suzuki; Honoo Satake
Journal:  J Biol Chem       Date:  2015-12-07       Impact factor: 5.157

10.  Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models.

Authors:  Natalie O Karpinich; Samantha L Hoopes; Daniel O Kechele; Patricia M Lenhart; Kathleen M Caron
Journal:  Curr Hypertens Rev       Date:  2011-12
  10 in total

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