Literature DB >> 15501446

Aurora kinases in spindle assembly and chromosome segregation.

Daniel Ducat1, Yixian Zheng.   

Abstract

The Aurora kinase family consists of three members, Aurora A, B, and C. The Aurora A and B kinases have emerged as essential regulators of cell division. While Aurora A kinase is implicated in regulating mitotic entry, centrosome maturation, and spindle assembly, Aurora B is required for correct chromosome segregation and cytokinesis. In this review, we summarize the roles of Aurora A and B in spindle assembly and chromosome segregation.

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Year:  2004        PMID： 15501446     DOI： 10.1016/j.yexcr.2004.08.016

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  61 in total

1.  Phase I study of barasertib (AZD1152), a selective inhibitor of Aurora B kinase, in patients with advanced solid tumors.

Authors:  Gary K Schwartz; Richard D Carvajal; Rachel Midgley; Scott J Rodig; Paul K Stockman; Ozlem Ataman; David Wilson; Shampa Das; Geoffrey I Shapiro
Journal:  Invest New Drugs       Date:  2012-06-02       Impact factor: 3.850

Review 2.  Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins.

Authors:  Nana Zheng; Zhiwei Wang; Wenyi Wei
Journal:  Int J Biochem Cell Biol       Date:  2016-02-06       Impact factor: 5.085

3.  The C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase.

Authors:  Zhenbo Han; Gary M Riefler; Jennifer R Saam; Susan E Mango; Jill M Schumacher
Journal:  Curr Biol       Date:  2005-05-24       Impact factor: 10.834

4.  Changing roles of aurora-B kinase in two life cycle stages of Trypanosoma brucei.

Authors:  Ziyin Li; C C Wang
Journal:  Eukaryot Cell       Date:  2006-07

5.  A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown.

Authors:  Nathan Portier; Anjon Audhya; Paul S Maddox; Rebecca A Green; Alexander Dammermann; Arshad Desai; Karen Oegema
Journal:  Dev Cell       Date:  2007-04       Impact factor: 12.270

6.  A pathway containing the Ipl1/aurora protein kinase and the spindle midzone protein Ase1 regulates yeast spindle assembly.

Authors:  Chitra V Kotwaliwale; Stéphanie Buvelot Frei; Bodo M Stern; Sue Biggins
Journal:  Dev Cell       Date:  2007-09       Impact factor: 12.270

7.  Aurora A, mitotic entry, and spindle bipolarity.

Authors:  Quentin Liu; Joan V Ruderman
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-31       Impact factor: 11.205

Review 8.  Update on aurora kinase inhibitors in gynecologic malignancies.

Authors:  Xia Tao; Hye S Chon; Siqing Fu; John J Kavanagh; Wei Hu
Journal:  Recent Pat Anticancer Drug Discov       Date:  2008-11       Impact factor: 4.169

Review 9.  Chromatin-modifying enzymes as therapeutic targets--Part 2.

Authors:  Brian R Keppler; Trevor K Archer
Journal:  Expert Opin Ther Targets       Date:  2008-11       Impact factor: 6.902

10.  An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2.

Authors:  Todd R Heallen; Henry P Adams; Tokiko Furuta; Koen J Verbrugghe; Jill M Schumacher
Journal:  Dev Cell       Date:  2008-10       Impact factor: 12.270
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