Literature DB >> 15501196

Spinal neural cyclooxygenase-2 mediates pain caused in a rat model of lumbar disk herniation.

Seiji Ohtori1, Kazuhisa Takahashi, Yasuchika Aoki, Hideo Doya, T Ozawa, Tomoko Saito, Hideshige Moriya.   

Abstract

UNLABELLED: Application of nucleus pulposus to nerve root generates radicular pain. We demonstrated that these animals showed allodynia for 2 weeks, and cyclooxygenase-2 (COX-2) immunoreactivities were up-regulated in the spinal dorsal horn. COX-2 immunoreactivities were shown in neurons; however, they were not in astrocytes. Intrathecal administration of an antibody to COX-2 decreased allodynia. Our results suggest that COX-2 in spinal cord might be a target for treatment of patients with nerve root pain caused by lumbar disk herniation. PERSPECTIVE: Neural COX-2 might mediate nerve root pain in the spinal cord caused by lumbar disk herniation in rats.

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Year:  2004        PMID： 15501196     DOI： 10.1016/j.jpain.2004.06.004

Source DB:  PubMed          Journal:  J Pain        ISSN： 1526-5900            Impact factor:   5.820


  13 in total

1.  Activation of NMDA receptor is associated with up-regulation of COX-2 expression in the spinal dorsal horn during nociceptive inputs in rats.

Authors:  Shu-Qin Li; Yan-Li Xing; Wei-Na Chen; Shu-Ling Yue; Li Li; Wen-Bin Li
Journal:  Neurochem Res       Date:  2009-04-01       Impact factor: 3.996

2.  Evaluation of behavior and expression of NaV1.7 in dorsal root ganglia after sciatic nerve compression and application of nucleus pulposus in rats.

Authors:  Michiaki Mukai; Yoshihiro Sakuma; Miyako Suzuki; Sumihisa Orita; Kazuyo Yamauchi; Gen Inoue; Yasuchika Aoki; Tetsuhiro Ishikawa; Masayuki Miyagi; Hiroto Kamoda; Gou Kubota; Yasuhiro Oikawa; Kazuhide Inage; Takeshi Sainoh; Jun Sato; Junichi Nakamura; Masashi Takaso; Tomoaki Toyone; Kazuhisa Takahashi; Seiji Ohtori
Journal:  Eur Spine J       Date:  2013-11-20       Impact factor: 3.134

3.  Transforaminal epidural Etanercept for the treatment of prolapsed lumbar intervertebral disc induced sciatica.

Authors:  Ashish Dagar; Ramesh Kumar; Abhishek Kashyap; Vinay Prabhat; Hitesh Lal; Lalit Kumar
Journal:  J Clin Orthop Trauma       Date:  2016-10-25

4.  Nuclear factor-kappa B decoy suppresses nerve injury and improves mechanical allodynia and thermal hyperalgesia in a rat lumbar disc herniation model.

Authors:  Munetaka Suzuki; Gen Inoue; Takefumi Gemba; Tomoko Watanabe; Toshinori Ito; Takana Koshi; Kazuyo Yamauchi; Masaomi Yamashita; Sumihisa Orita; Yawara Eguchi; Nobuyasu Ochiai; Shunji Kishida; Masashi Takaso; Yasuchika Aoki; Kazuhisa Takahashi; Seiji Ohtori
Journal:  Eur Spine J       Date:  2009-03-24       Impact factor: 3.134

5.  Osthole, a herbal compound, alleviates nucleus pulposus-evoked nociceptive responses through the suppression of overexpression of acid-sensing ion channel 3 (ASIC3) in rat dorsal root ganglion.

Authors:  Qiu-Lan He; Yuling Chen; Jian Qin; Sui-Lin Mo; Ming Wei; Jin-Jun Zhang; Mei-Na Li; Xue-Nong Zou; Shu-Feng Zhou; Xiao-Wu Chen; Lai-Bao Sun
Journal:  Med Sci Monit       Date:  2012-06

6.  Changes in the Expressions of Iba1 and Calcitonin Gene-Related Peptide in Adjacent Lumbar Spinal Segments after Lumbar Disc Herniation in a Rat Model.

Authors:  Hee Kyung Cho; Sang Ho Ahn; So-Yeon Kim; Mi-Jung Choi; Se Jin Hwang; Yun Woo Cho
Journal:  J Korean Med Sci       Date:  2015-11-30       Impact factor: 2.153

7.  Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model.

Authors:  Xiaoyan Zhu; Qian Li; Ruimin Chang; Dong Yang; Zongbing Song; Qulian Guo; Changsheng Huang
Journal:  PLoS One       Date:  2014-03-06       Impact factor: 3.240

8.  Evaluation of behavior and expression of receptor activator of nuclear factor-kappa B ligand in dorsal root Ganglia after sciatic nerve compression and application of nucleus pulposus in rats.

Authors:  Yoshiyuki Matsuyama; Yoshihiro Sakuma; Miyako Suzuki; Sumihisa Orita; Kazuyo Yamauchi; Gen Inoue; Yasuchika Aoki; Tetsuhiro Ishikawa; Masayuki Miyagi; Hiroto Kamoda; Gou Kubota; Yasuhiro Oikawa; Kazuhide Inage; Takeshi Sainoh; Jun Sato; Junichi Nakamura; Tomoaki Toyone; Kazuhisa Takahashi; Seiji Ohtori
Journal:  Asian Spine J       Date:  2014-10-18

9.  Up-Regulation of Pain Behavior and Glial Activity in the Spinal Cord after Compression and Application of Nucleus Pulposus onto the Sciatic Nerve in Rats.

Authors:  Masaki Norimoto; Yoshihiro Sakuma; Miyako Suzuki; Sumihisa Orita; Kazuyo Yamauchi; Gen Inoue; Yasuchika Aoki; Tetsuhiro Ishikawa; Masayuki Miyagi; Hiroto Kamoda; Gou Kubota; Yasuhiro Oikawa; Kazuhide Inage; Takeshi Sainoh; Jun Sato; Junichi Nakamura; Tomoaki Toyone; Kazuhisa Takahashi; Seiji Ohtori
Journal:  Asian Spine J       Date:  2014-10-18

10.  Efficacy of Direct Injection of Etanercept into Knee Joints for Pain in Moderate and Severe Knee Osteoarthritis.

Authors:  Seiji Ohtori; Sumihisa Orita; Kazuyo Yamauchi; Yawara Eguchi; Nobuyasu Ochiai; Shunji Kishida; Kazuki Kuniyoshi; Yasuchika Aoki; Junichi Nakamura; Tetsuhiro Ishikawa; Masayuki Miyagi; Hiroto Kamoda; Miyako Suzuki; Gou Kubota; Yoshihiro Sakuma; Yasuhiro Oikawa; Kazuhide Inage; Takeshi Sainoh; Jun Sato; Yasuhiro Shiga; Koki Abe; Kazuki Fujimoto; Hiroto Kanamoto; Tomoaki Toyone; Gen Inoue; Kazuhisa Takahashi
Journal:  Yonsei Med J       Date:  2015-09       Impact factor: 2.759
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