| Literature DB >> 15501067 |
K Shankaran1, Karla L Donnelly, Shrenik K Shah, Charles G Caldwell, Ping Chen, William K Hagmann, Malcolm Maccoss, John L Humes, Stephen G Pacholok, Theresa M Kelly, Stephan K Grant, Kenny K Wong.
Abstract
A series of 3- and 5-imino analogs from oxazepane, thiazepane, and diazepane was prepared and evaluated as inhibitors of human nitric oxide synthesis (NOS). The most potent iNOS inhibitor was the thiazepane analog 25 (IC(50) = 0.19 microM).Entities:
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Year: 2004 PMID： 15501067 DOI： 10.1016/j.bmcl.2004.09.019
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823