Gram positive (Bacillus cereus, B. subtilis), Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria, and Candida albicans as a representative of fungi were used for screening the in vitro antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series bearing different substituents, synthesized by us using the palladium-catalyzed C-N coupling methodology. The minimal inhibitory concentration (MIC) and structure-activity relationships (SARs) were evaluated.
Gram positive (Bacillus cereus, n class="Species">B. subtilis), Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria, and Candida albicans as a representative of fungi were used for screening the in vitro antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series bearing different substituents, synthesized by us using the palladium-catalyzed C-N coupling methodology. The minimal inhibitory concentration (MIC) and structure-activity relationships (SARs) were evaluated.
Authors: Prerna J Masih; Tanay Kesharwani; Elivet Rodriguez; Mia A Vertudez; Mina L Motakhaveri; Terelan K Le; Minh Kieu T Tran; Matthew R Cloyd; Cory T Kornman; Aimee M Phillips Journal: Pharmaceuticals (Basel) Date: 2021-12-28