Venous modulation of ventricular preload.

The objective of this discussion has been to describe a simple conceptual model of the circulation that emphasizes the role of the venous capacitance vasculature and is based on simplified vascular pressure-volume relationships. First, it is hoped that this approach will avoid some of the misunderstandings and contradictions that have resulted from an approach to the veins that is based on pressure-flow relationships. As mentioned at the outset, the confusion between venous volume and flow has led to the anomalous but logical conclusion that decreased venous pooling corresponds to increased venous return (which must equal cardiac output in the steady state). Second, it is also hoped that the model will prove to be a useful starting point from which to better understand how the veins modulate cardiac output in the normal individual and how alterations in venous capacitance affect the hemodynamic profile of congestive heart failure.