PURPOSE: To investigate the expression of matrix metalloproteinases (MMPs) in choroidal neovascular membranes with age-related macular degeneration (AMD). METHODS: Seventeen choroidal neovascular membranes surgically removed from AMD patients with pars plana vitrectomy and subretinal membranes peeling were investigated. The expression of MMP-2 and MMP-9 was determined with immunohistochemical technique. RESULTS: Immunohistochemistry staining in choroidal neovascular membranes for MMP-2 and MMP-9 was observed in 17 specimens. There was no detective of MMP-2 and MMP-9 in normal retinas. CONCLUSIONS: MMP-2 and MMP-9 were found in choroidal neovascular membranes, may degrade the Bruch membrane and be associated with the perforation of new vessels into Bruch membrane, involving a basic pathogenic process of AMD.
PURPOSE: To investigate the expression of matrix metalloproteinases (MMPs) in choroidal neovascular membranes with age-related macular degeneration (AMD). METHODS: Seventeen choroidal neovascular membranes surgically removed from AMDpatients with pars plana vitrectomy and subretinal membranes peeling were investigated. The expression of MMP-2 and MMP-9 was determined with immunohistochemical technique. RESULTS: Immunohistochemistry staining in choroidal neovascular membranes for MMP-2 and MMP-9 was observed in 17 specimens. There was no detective of MMP-2 and MMP-9 in normal retinas. CONCLUSIONS:MMP-2 and MMP-9 were found in choroidal neovascular membranes, may degrade the Bruch membrane and be associated with the perforation of new vessels into Bruch membrane, involving a basic pathogenic process of AMD.
Authors: Zhongjie Fu; Raffael Liegl; Zhongxiao Wang; Yan Gong; Chi-Hsiu Liu; Ye Sun; Bertan Cakir; Samuel B Burnim; Steven S Meng; Chatarina Löfqvist; John Paul SanGiovanni; Ann Hellström; Lois E H Smith Journal: Invest Ophthalmol Vis Sci Date: 2017-08-01 Impact factor: 4.799