| Literature DB >> 15499023 |
D E Nelson1, A E C Ihekwaba, M Elliott, J R Johnson, C A Gibney, B E Foreman, G Nelson, V See, C A Horton, D G Spiller, S W Edwards, H P McDowell, J F Unitt, E Sullivan, R Grimley, N Benson, D Broomhead, D B Kell, M R H White.
Abstract
Signaling by the transcription factor nuclear factor kappa B (NF-kappaB) involves its release from inhibitor kappa B (IkappaB) in the cytosol, followed by translocation into the nucleus. NF-kappaB regulation of IkappaBalpha transcription represents a delayed negative feedback loop that drives oscillations in NF-kappaB translocation. Single-cell time-lapse imaging and computational modeling of NF-kappaB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with increased IkappaBalpha transcription. Transcription of target genes depended on oscillation persistence, involving cycles of RelA phosphorylation and dephosphorylation. The functional consequences of NF-kappaB signaling may thus depend on number, period, and amplitude of oscillations.Entities:
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Year: 2004 PMID： 15499023 DOI： 10.1126/science.1099962
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728