| Literature DB >> 15497957 |
Bojan Bister1, Simone Keller, Heike I Baumann, Graeme Nicholson, Stefan Weist, Günther Jung, Roderich D Süssmuth, Friedrich Jüttner.
Abstract
A new depsipeptide, cyanopeptolin 963 A (1), was isolated from an axenic strain of the toxic freshwater cyanobacterium Microcystis PCC 7806. The structure of this compound was elucidated by chemical and spectroscopic analyses, including high-resolution ESI-FTICR-MS, 2-D NMR, and GC-MS of the hydrolysate. The major structural difference compared to previously characterized cyanopeptolins of this strain is the replacement of the basic amino acid in position 3 by L-tyrosine. Compound 1 displayed inhibitory activity against chymotrypsin with an IC50 value of 0.9 microM.Entities:
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Year: 2004 PMID： 15497957 DOI： 10.1021/np049828f
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050