Literature DB >> 15497946

Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.

Shugeng Cao1, Zhijie Gao, Shannon J Thomas, Sidney M Hecht, John S Lazo, David G I Kingston.   

Abstract

Bioassay-directed fractionation of an extract of the marine species Spongia sp. led to the discovery of the new sesquiterpenoid derivative 17-O-isoprenyldictyoceratin-C (1), the known sesquiterpenoid derivative dictyoceratin-C (2), and the sesquiterpenoid quinone ilimaquinone (3), in addition to the nucleoside 2'-deoxyuridine. The structure of the new compound 1 was determined on the basis of spectroscopic methods and by conversion of dictyoceratin-C (2) to 1.

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Year:  2004        PMID: 15497946     DOI: 10.1021/np049849+

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  9 in total

Review 1.  Targeting DNA polymerase ß for therapeutic intervention.

Authors:  Eva M Goellner; David Svilar; Karen H Almeida; Robert W Sobol
Journal:  Curr Mol Pharmacol       Date:  2012-01       Impact factor: 3.339

Review 2.  Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis.

Authors:  Satya Narayan; Ritika Sharma
Journal:  Life Sci       Date:  2015-09-01       Impact factor: 5.037

Review 3.  Marine pharmacology in 2003-4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Mark T Hamann
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2007-02-09       Impact factor: 3.228

4.  Bioactive isomalabaricane triterpenoids from Rhabdastrella globostellata that stabilize the binding of DNA polymerase beta to DNA.

Authors:  Jason A Clement; Mei Li; Sidney M Hecht; David G I Kingston
Journal:  J Nat Prod       Date:  2006-03       Impact factor: 4.050

Review 5.  The Role of Spongia sp. in the Discovery of Marine Lead Compounds.

Authors:  Patrícia Máximo; Luísa M Ferreira; Paula Branco; Pedro Lima; Ana Lourenço
Journal:  Mar Drugs       Date:  2016-07-23       Impact factor: 5.118

Review 6.  Reactivity and biological activity of the marine sesquiterpene hydroquinone avarol and related compounds from sponges of the order Dictyoceratida.

Authors:  Dusan Sladić; Miroslav J Gasić
Journal:  Molecules       Date:  2006-01-31       Impact factor: 4.411

7.  Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity.

Authors:  Choong-Hwan Kwak; Ling Jin; Jung Ho Han; Chang Woo Han; Eonmi Kim; MyoungLae Cho; Tae-Wook Chung; Sung-Jin Bae; Se Bok Jang; Ki-Tae Ha
Journal:  Int J Mol Sci       Date:  2020-08-21       Impact factor: 5.923

8.  Evaluation of antiproliferative and anti-inflammatory activities of methanol extract and its fractions from the Mediterranean sponge.

Authors:  Afef Dellai; Monia Deghrigue; Audrey Laroche-Clary; Hedi Ben Masour; Nabil Chouchane; Jacques Robert; Abderrahman Bouraoui
Journal:  Cancer Cell Int       Date:  2012-05-15       Impact factor: 5.722

9.  Pyramidamycins A-D and 3-hydroxyquinoline-2-carboxamide; cytotoxic benzamides from Streptomyces sp. DGC1.

Authors:  Khaled A Shaaban; Micah D Shepherd; Tamer A Ahmed; S Eric Nybo; Markos Leggas; Jürgen Rohr
Journal:  J Antibiot (Tokyo)       Date:  2012-10-10       Impact factor: 2.649

  9 in total

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