OBJECTIVES: To evaluate the use in an emergency department of a new D-dimer assay (Simplify D-dimer) as a screening test for deep vein thrombosis (DVT). METHODS: 187 outpatients with clinical features suspicious of acute DVT were entered into this study. A Simplify D-dimer test was performed in the emergency department on all patients. A SimpliRED D-dimer test and a semi-automated latex agglutination assay (Auto-D-dimer 700 on a Thromboscreen 400C analyser) were performed in the haematology laboratory. All patients were investigated with contrast venography to confirm or exclude the diagnosis of DVT. RESULTS: The Simplify test had a sensitivity of 94.1% and a negative predictive value (NPV) of 94.8%. These results compared favourably with the SimpliRED test (sensitivity 74.5%, NPV 89.7%) and the latex agglutination assay (sensitivity 90.2%, NPV 92.2%). This increased sensitivity was at the cost of a lower specificity, the specificity of the three d-dimer tests being Simplify 40.4%, SimpliRED 83.1%, and latex agglutination 43.4%. CONCLUSIONS: Simplify proved to be a rapid and easy to use test and may be useful for use in the emergency department as part of a diagnostic algorithm for deep vein thrombosis. Further larger scale studies are needed.
OBJECTIVES: To evaluate the use in an emergency department of a new D-dimer assay (Simplify D-dimer) as a screening test for deep vein thrombosis (DVT). METHODS: 187 outpatients with clinical features suspicious of acute DVT were entered into this study. A Simplify D-dimer test was performed in the emergency department on all patients. A SimpliRED D-dimer test and a semi-automated latex agglutination assay (Auto-D-dimer 700 on a Thromboscreen 400C analyser) were performed in the haematology laboratory. All patients were investigated with contrast venography to confirm or exclude the diagnosis of DVT. RESULTS: The Simplify test had a sensitivity of 94.1% and a negative predictive value (NPV) of 94.8%. These results compared favourably with the SimpliRED test (sensitivity 74.5%, NPV 89.7%) and the latex agglutination assay (sensitivity 90.2%, NPV 92.2%). This increased sensitivity was at the cost of a lower specificity, the specificity of the three d-dimer tests being Simplify 40.4%, SimpliRED 83.1%, and latex agglutination 43.4%. CONCLUSIONS: Simplify proved to be a rapid and easy to use test and may be useful for use in the emergency department as part of a diagnostic algorithm for deep vein thrombosis. Further larger scale studies are needed.
Authors: F van der Graaf; H van den Borne; M van der Kolk; P J de Wild; G W Janssen; S H van Uum Journal: Thromb Haemost Date: 2000-02 Impact factor: 5.249
Authors: T Mauron; I Baumgartner; A Z'Brun; F Demarmels Biasiutti; M Redondo; D D Do; B Lämmle; W A Wuillemin Journal: Thromb Haemost Date: 1998-06 Impact factor: 5.249
Authors: C Kearon; J S Ginsberg; J Douketis; M Crowther; P Brill-Edwards; J I Weitz; J Hirsh Journal: Ann Intern Med Date: 2001-07-17 Impact factor: 25.391
Authors: Clive Kearon; Sameer Parpia; Frederick A Spencer; Trevor Baglin; Scott M Stevens; Kenneth A Bauer; Steven R Lentz; Craig M Kessler; James D Douketis; Stephan Moll; Scott Kaatz; Sam Schulman; Jean M Connors; Jeffrey S Ginsberg; Luciana Spadafora; Vinai Bhagirath; Patricia C Liaw; Jeffrey I Weitz; Jim A Julian Journal: Blood Date: 2018-02-28 Impact factor: 22.113