| Literature DB >> 15496109 |
Hideyuki Onodera1, Atsuhiro Hasegawa, Noriko Tsumagari, Ryuichiro Nakai, Tatsuhiro Ogawa, Yutaka Kanda.
Abstract
[structure: see text] Eight new compounds, MPC1001 and MPC1001B-H, were isolated from the fungus Cladorrhinum sp. KY4922. Multiple NMR experiments and CD data revealed MPC1001 to be an O-methyl derivative of emestrin, a 15-membered antifungal antibiotic containing a unique epidithiodioxopiperazine skeleton. Other compounds were elucidated to be structurally related novel analogues. MPC1001 and the analogues exerted potent antiproliferative activities against a human tumor cell line.Entities:
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Year: 2004 PMID： 15496109 DOI： 10.1021/ol048202d
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005