Literature DB >> 15496099

Synthesis of polysubstituted 4-fluoroquinolinones.

Alexander S Kiselyov1, Evgueni L Piatnitski, Jacqueline Doody.   

Abstract

[reaction: see text] A convenient one-pot synthesis of 4-fluoroquinolinones that are active against KDR kinase is described. The mechanism of the reaction is believed to involve the formation of a quinone methide intermediate.

Entities:  

Year:  2004        PMID: 15496099     DOI: 10.1021/ol048257f

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

1.  Lewis acid-promoted cascade reaction for the synthesis of Michael acceptors and its application in a dimerization reaction.

Authors:  Xiao-Jing Zhao; Jie Zhao; Xin Sun; Ji-Kai Liu; Bin Wu
Journal:  Tetrahedron       Date:  2017-05-06       Impact factor: 2.457

  1 in total

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