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Literature DB >> 15494027

Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.

Abstract

The cytoskeletal proteins talin and vinculin form part of a macromolecular complex on the cytoplasmic face of integrin-mediated cellular junctions with the extracellular matrix. Recent genetic, biochemical and structural data show that talin is essential for the assembly of such junctions, whereas vinculin appears to be important in regulating adhesion dynamics and cell migration.

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Year: 2004 PMID： 15494027 DOI： 10.1042/BST0320831

Source DB: PubMed Journal: Biochem Soc Trans ISSN： 0300-5127 Impact factor: 5.407

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Cited

67 in total

Review 1. The switchable integrin adhesome.

Authors: Ronen Zaidel-Bar; Benjamin Geiger
Journal: J Cell Sci Date: 2010-05-01 Impact factor: 5.285

2. The NPIY motif in the integrin beta1 tail dictates the requirement for talin-1 in outside-in signaling.

Authors: Bethsaida Nieves; Christopher W Jones; Rachel Ward; Yasutaka Ohta; Carlos G Reverte; Susan E LaFlamme
Journal: J Cell Sci Date: 2010-03-23 Impact factor: 5.285

3. Vinculin binding in its closed conformation by a helix addition mechanism.

Authors: Guy Tran Van Nhieu; Tina Izard
Journal: EMBO J Date: 2007-10-11 Impact factor: 11.598

4. Integrins contribute to initial morphological development and process outgrowth in rat adult hippocampal progenitor cells.

Authors: Matthew M Harper; Eun-Ah Ye; Christopher C Blong; Mark L Jacobson; Donald S Sakaguchi
Journal: J Mol Neurosci Date: 2009-06-05 Impact factor: 3.444

Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.

Review 1. The switchable integrin adhesome.

2. The NPIY motif in the integrin beta1 tail dictates the requirement for talin-1 in outside-in signaling.

3. Vinculin binding in its closed conformation by a helix addition mechanism.

4. Integrins contribute to initial morphological development and process outgrowth in rat adult hippocampal progenitor cells.

5. Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling.

6. Differences in regulation of Drosophila and vertebrate integrin affinity by talin.

7. Cooperativity between integrin activation and mechanical stress leads to integrin clustering.

8. A four actin-binding protein signature model for poor prognosis of patients with esophageal squamous cell carcinoma.

9. A helix replacement mechanism directs metavinculin functions.

10. Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration.