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Literature DB >> 15494001

Mechanisms of elongation on the ribosome: dynamics of a macromolecular machine.

W Wintermeyer¹, F Peske, M Beringer, K B Gromadski, A Savelsbergh, M V Rodnina.

Abstract

Protein synthesis in the cell is performed on ribosomes, large ribonucleoprotein particles, which in bacteria consist of three RNA molecules and over 50 proteins. This review summarizes recent progress in understanding the mechanisms of the elongation phase of protein synthesis. Results from rapid kinetic analysis of elongation reactions are discussed in the light of recent structural data.

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Year: 2004 PMID： 15494001 DOI： 10.1042/BST0320733

Source DB: PubMed Journal: Biochem Soc Trans ISSN： 0300-5127 Impact factor: 5.407

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Cited

50 in total

1. Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis.

Authors: Chunlai Chen; Benjamin Stevens; Jaskiran Kaur; Zeev Smilansky; Barry S Cooperman; Yale E Goldman
Journal: Proc Natl Acad Sci U S A Date: 2011-10-03 Impact factor: 11.205

2. Codon-Anticodon Recognition in the Bacillus subtilis glyQS T Box Riboswitch: RNA-DEPENDENT CODON SELECTION OUTSIDE THE RIBOSOME.

Authors: Enrico Caserta; Liang-Chun Liu; Frank J Grundy; Tina M Henkin
Journal: J Biol Chem Date: 2015-07-30 Impact factor: 5.157

Mechanisms of elongation on the ribosome: dynamics of a macromolecular machine.

1. Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis.

2. Codon-Anticodon Recognition in the Bacillus subtilis glyQS T Box Riboswitch: RNA-DEPENDENT CODON SELECTION OUTSIDE THE RIBOSOME.

3. Reverse translocation of tRNA in the ribosome.

4. Kinetically competent intermediates in the translocation step of protein synthesis.

5. Structures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocation.

6. Genetic analysis of the E site during RF2 programmed frameshifting.

7. Following translation by single ribosomes one codon at a time.

8. Anticodon loop mutations perturb reading frame maintenance by the E site tRNA.

Review 9. You're one in a googol: optimizing genes for protein expression.

Review 10. Ribosomal translocation: one step closer to the molecular mechanism.