Literature DB >> 15494000

HAUSP/USP7 as an Epstein-Barr virus target.

M N Holowaty1, L Frappier.   

Abstract

USP7 (also called HAUSP) is a de-ubiquitinating enzyme recently identified as a key regulator of the p53-mdm2 pathway, which stabilizes both p53 and mdm2. We have discovered that the Epstein-Barr nuclear antigen 1 protein of Epstein-Barr virus binds with high affinity to USP7 and disrupts the USP7-p53 interaction. The results have important implications for the role of Epstein-Barr nuclear antigen 1 in the cellular immortalization that is typical of an Epstein-Barr virus latent infection.

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Year:  2004        PMID： 15494000     DOI： 10.1042/BST0320731

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  24 in total

1.  Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication.

Authors:  Tsai-Ling Liao; Chung-Yi Wu; Wen-Chi Su; King-Song Jeng; Michael M C Lai
Journal:  EMBO J       Date:  2010-10-05       Impact factor: 11.598

2.  A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection.

Authors:  Sara Gredmark; Christian Schlieker; Victor Quesada; Eric Spooner; Hidde L Ploegh
Journal:  J Virol       Date:  2007-07-18       Impact factor: 5.103

3.  HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.

Authors:  Seemana Bhattacharya; Mrinal K Ghosh
Journal:  Cell Oncol (Dordr)       Date:  2015-04-30       Impact factor: 6.730

Review 4.  Regulation of pluripotency and differentiation by deubiquitinating enzymes.

Authors:  B Suresh; J Lee; H Kim; S Ramakrishna
Journal:  Cell Death Differ       Date:  2016-06-10       Impact factor: 15.828

Review 5.  Computational methods for de novo protein design and its applications to the human immunodeficiency virus 1, purine nucleoside phosphorylase, ubiquitin specific protease 7, and histone demethylases.

Authors:  M L Bellows; C A Floudas
Journal:  Curr Drug Targets       Date:  2010-03       Impact factor: 3.465

6.  KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation.

Authors:  Gretchen L Bentz; Anjali Bheda-Malge; Ling Wang; Julia Shackelford; Blossom Damania; Joseph S Pagano
Journal:  Virology       Date:  2013-11-08       Impact factor: 3.616

7.  Epstein-Barr virus latent antigens EBNA3C and EBNA1 modulate epithelial to mesenchymal transition of cancer cells associated with tumor metastasis.

Authors:  Nivedita Gaur; Jaya Gandhi; Erle S Robertson; Subhash C Verma; Rajeev Kaul
Journal:  Tumour Biol       Date:  2014-12-13

8.  A gammaherpesvirus ubiquitin-specific protease is involved in the establishment of murine gammaherpesvirus 68 infection.

Authors:  Sara Gredmark-Russ; Marisa K Isaacson; Lisa Kattenhorn; Evelyn J Cheung; Nicki Watson; Hidde L Ploegh
Journal:  J Virol       Date:  2009-08-12       Impact factor: 5.103

9.  Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.

Authors:  Fuming Yi; Abhik Saha; Masanao Murakami; Pankaj Kumar; Jason S Knight; Qiliang Cai; Tathagata Choudhuri; Erle S Robertson
Journal:  Virology       Date:  2009-04-24       Impact factor: 3.616

10.  Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation.

Authors:  Robert Valentine; Christopher W Dawson; Chunfang Hu; Khilan M Shah; Thomas J Owen; Kathryn L Date; Sonia P Maia; Jianyong Shao; John R Arrand; Lawrence S Young; John D O'Neil
Journal:  Mol Cancer       Date:  2010-01-05       Impact factor: 27.401
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