| Literature DB >> 15493914 |
Jens Brunner1, Roland Kraemer.
Abstract
A copper(II)-quenched molecular beacon was prepared by attaching fluorescein to the 3'-end and a copper(II) complex to the 5'-end of DNA. In the presence of complementary DNA, copper(II) and dye are spatially separated in the duplex and fluorescence increases up to 15-fold, with excellent discrimination of single base mismatches.Entities:
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Year: 2004 PMID： 15493914 DOI： 10.1021/ja047252a
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419