| Literature DB >> 15493907 |
Keiji Itaka1, Naoki Kanayama, Nobuhiro Nishiyama, Woo-Dong Jang, Yuichi Yamasaki, Kozo Nakamura, Hiroshi Kawaguchi, Kazunori Kataoka.
Abstract
An siRNA nanocarrier formed through self-assembly of PEG-based block catiomer possessing two distinct amino groups with different pKa values in a side chain was developed. This design provided the carrier with a sufficient siRNA complexation and an assumed buffering capacity in the endosomes, allowing it to exhibit remarkable gene knockdown abilities as well as sufficient serum tolerability.Entities:
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Year: 2004 PMID： 15493907 DOI： 10.1021/ja047174r
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419