Literature DB >> 15493261

The T-cell response to haptenated insulins. II. The antibody response.

M Flory1, G R Wallace, K Oettel, B M Chain.   

Abstract

As described in an accompanying paper, trinitrophenyl (TNP) modification of pork insulin (PI) at the A1 glycine position allows this molecule to stimulate a proliferative response in H-2b (B10) mice. We now show that this antigen stimulates low IgG responses in the same strain of mice. Our results show that T-cell help and proliferation may therefore be regulated independently.

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Year:  1989        PMID： 15493261      PMCID： PMC1385118     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  10 in total

1.  Development of T cell clones reactive to two defined restriction elements in conjunction with two defined epitopes of antigen.

Authors:  E Spaeth; E Rüde
Journal:  Eur J Immunol       Date:  1985-12       Impact factor: 5.532

2.  Carrier function of the polypeptides (T,G)-A-L and (H,G)-A--L in high and low responder mice.

Authors:  J Wrede; E Rüde; R Thumb; M Meyer-Delius
Journal:  Eur J Immunol       Date:  1973-12       Impact factor: 5.532

3.  Binding of immunogenic peptides to Ia histocompatibility molecules.

Authors:  B P Babbitt; P M Allen; G Matsueda; E Haber; E R Unanue
Journal:  Nature       Date:  1985 Sep 26-Oct 2       Impact factor: 49.962

4.  Fine specificity of cloned insulin-specific T cell hybridomas: evidence supporting a role for tertiary conformation.

Authors:  L H Glimcher; J A Schroer; C Chan; E M Shevach
Journal:  J Immunol       Date:  1983-12       Impact factor: 5.422

5.  Genetics of insulin-specific helper and suppressor T cells in nonresponder mice.

Authors:  P E Jensen; J A Kapp
Journal:  J Immunol       Date:  1985-11       Impact factor: 5.422

6.  Repertoires of T cells directed against a large protein antigen, beta-galactosidase. I. Helper cells have a more restricted specificity repertoire than proliferative cells.

Authors:  U Krzych; A V Fowler; A Miller; E E Sercarz
Journal:  J Immunol       Date:  1982-04       Impact factor: 5.422

7.  Mapping epitopes on the insulin molecule using monoclonal antibodies.

Authors:  J A Schroer; T Bender; R J Feldmann; K J Kim
Journal:  Eur J Immunol       Date:  1983-09       Impact factor: 5.532

8.  Immune response gene control of determinant selection. II. Genetic control of the murine T lymphocyte proliferative response to insulin.

Authors:  L J Rosenwasser; M A Barcinski; R H Schwartz; A S Rosenthal
Journal:  J Immunol       Date:  1979-07       Impact factor: 5.422

9.  T cells that help B cell responses to soluble antigen are distinguishable from those producing interleukin 2 on mitogenic or allogeneic stimulation.

Authors:  R P Arthur; D Mason
Journal:  J Exp Med       Date:  1986-04-01       Impact factor: 14.307

10.  Regulatory mechanisms in immune responses to heterologous insulins. II. Suppressor T cell activation associated with nonresponsiveness in H-2b mice.

Authors:  P E Jensen; C W Pierce; J A Kapp
Journal:  J Exp Med       Date:  1984-10-01       Impact factor: 14.307
  10 in total

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