| Literature DB >> 15491853 |
Snezana M Mirkov1, Aleksandar N Djordjevic, Nebojsa L Andric, Silvana A Andric, Tatjana S Kostic, Gordana M Bogdanovic, Mirjana B Vojinovic-Miloradov, Radmila Z Kovacevic.
Abstract
Investigation of the possible nitric oxide-scavenging activity of hydroxylated derivative of fullerene, fullerenol C60(OH)24, demonstrated that it expressed direct scavenging activity toward nitric oxide radical (NO) liberated within solution of sodium nitroprusside (SNP), a well known NO donor. In parallel, pre-treatment (30') with intratesticular injection of fullerenol (60 microg/each testis) prevented NO-induced decrease of catalase, glutathione transferase and glutathione peroxidase activities in the denucleated fraction of interstitial testicular cells of adult rats 2 h after intratesticular injection of SNP (20 microg/each testis). In addition, fullerenol decreased formation of thiobarbituric acid-reactive substances (TBA-RS) with similar efficiency as butylated hydroxy toluen (BHT), a well known antioxidant. Also, fullerenol expressed certain scavenging activity toward superoxide anion (O2-) in xanthine/xanthine oxidase system. In summary, results obtained in this study confirmed free radical-scavenging activity of fullerenol, and according to our knowledge, it is the first evidence of direct NO-quenching activity of hydroxylated C60 derivative in different milieu.Entities:
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Year: 2004 PMID： 15491853 DOI： 10.1016/j.niox.2004.08.003
Source DB: PubMed Journal: Nitric Oxide ISSN： 1089-8603 Impact factor: 4.427