A Torbé1, R Czajka. 1. Department of Obstetrics and Perinatology of Pomeranian Medical University, Powstañców Wielkopolskich 72, 70-111 Szczecin, Poland. torbea@wp.pl
Abstract
OBJECTIVES: To compare the usefulness of evaluating cervico-vaginal concentrations of proinflammatory cytokines (interleukin [IL]-1alpha, IL-1beta, IL-6 and IL-8) and procalcitonin (PCT), as well as serum levels of C-reactive protein (CRP), leucocytosis and band form granulocytes in the prediction of preterm delivery (PTD). METHODS: A total of 65 pregnant women experiencing preterm labor (PTL) were enrolled in the study. Concentrations of the studied markers in women who delivered prematurely and in women who, after treatment, delivered at term were compared. Receiver operator characteristic (ROC) curve analysis was used for all study parameters. RESULTS: Cervico-vaginal IL-6 and procalcitonin as well as serum CRP concentrations were higher in women who delivered prematurely than in those who delivered near term. A cervico-vaginal IL-6 level greater than 660 pg/ml was the best predictive value of preterm delivery (sensitivity, 50%; specificity 90%; positive predictive value [PPV], 85%; NPV, 62%; likelihood ratio, 5.17). Moreover, the area under the ROC curve of 0.75 for cervico-vaginal IL-6 was greater than for other markers. CONCLUSION: Although cervico-vaginal concentrations of procalcitonin and serum concentration of CRP are higher in women who deliver prematurely, only cervico-vaginal concentration of IL-6 is a good predictor of preterm delivery.
OBJECTIVES: To compare the usefulness of evaluating cervico-vaginal concentrations of proinflammatory cytokines (interleukin [IL]-1alpha, IL-1beta, IL-6 and IL-8) and procalcitonin (PCT), as well as serum levels of C-reactive protein (CRP), leucocytosis and band form granulocytes in the prediction of preterm delivery (PTD). METHODS: A total of 65 pregnant women experiencing preterm labor (PTL) were enrolled in the study. Concentrations of the studied markers in women who delivered prematurely and in women who, after treatment, delivered at term were compared. Receiver operator characteristic (ROC) curve analysis was used for all study parameters. RESULTS: Cervico-vaginal IL-6 and procalcitonin as well as serum CRP concentrations were higher in women who delivered prematurely than in those who delivered near term. A cervico-vaginal IL-6 level greater than 660 pg/ml was the best predictive value of preterm delivery (sensitivity, 50%; specificity 90%; positive predictive value [PPV], 85%; NPV, 62%; likelihood ratio, 5.17). Moreover, the area under the ROC curve of 0.75 for cervico-vaginal IL-6 was greater than for other markers. CONCLUSION: Although cervico-vaginal concentrations of procalcitonin and serum concentration of CRP are higher in women who deliver prematurely, only cervico-vaginal concentration of IL-6 is a good predictor of preterm delivery.
Authors: Steve N Caritis; Gary Hankins; Mary Hebert; David M Haas; Mahmoud Ahmed; Hyagriv Simhan; Laura A Haneline; John Harris; Justine Chang; Alyssa Stephenson Famy; Patrick Yorio; Zhaoxia Ren; Mary E D'Alton; Raman Venkataramanan Journal: Am J Perinatol Date: 2017-11-15 Impact factor: 1.862
Authors: Waranuch Pitiphat; Matthew W Gillman; Kaumudi J Joshipura; Paige L Williams; Chester W Douglass; Janet W Rich-Edwards Journal: Am J Epidemiol Date: 2005-10-19 Impact factor: 4.897
Authors: Jose G Cecatti; Renato T Souza; Karolina Sulek; Maria L Costa; Louise C Kenny; Lesley M McCowan; Rodolfo C Pacagnella; Silas G Villas-Boas; Jussara Mayrink; Renato Passini; Kleber G Franchini; Philip N Baker Journal: BMC Pregnancy Childbirth Date: 2016-08-08 Impact factor: 3.007