BACKGROUND: Antigliadin antibodies (AGA) have been reported in patients with psoriasis. OBJECTIVES: To determine if AGA and other coeliac disease (CD)-associated antibodies correlate with clinical features and activity in patients with psoriasis. METHODS: Patients with psoriasis (n = 130) were investigated for serum IgG and IgA AGA, IgA antitransglutaminase antibody and IgA antiendomysial antibody. Disease characteristics and associated bowel and joint symptoms were determined. All patients were invited to undertake endoscopy with duodenal biopsy. RESULTS: A significantly higher proportion of patients with elevated CD-associated antibody levels was currently on or had previously required systemic immunosuppressants (methotrexate, ciclosporin or etretinate; P = 0.04) or psoralen plus ultraviolet A phototherapy (P = 0.03). One case of CD was diagnosed. CONCLUSIONS: The presence of CD-associated antibodies in psoriasis patients correlates with greater disease activity.
BACKGROUND: Antigliadin antibodies (AGA) have been reported in patients with psoriasis. OBJECTIVES: To determine if AGA and other coeliac disease (CD)-associated antibodies correlate with clinical features and activity in patients with psoriasis. METHODS:Patients with psoriasis (n = 130) were investigated for serum IgG and IgA AGA, IgA antitransglutaminase antibody and IgA antiendomysial antibody. Disease characteristics and associated bowel and joint symptoms were determined. All patients were invited to undertake endoscopy with duodenal biopsy. RESULTS: A significantly higher proportion of patients with elevated CD-associated antibody levels was currently on or had previously required systemic immunosuppressants (methotrexate, ciclosporin or etretinate; P = 0.04) or psoralen plus ultraviolet A phototherapy (P = 0.03). One case of CD was diagnosed. CONCLUSIONS: The presence of CD-associated antibodies in psoriasispatients correlates with greater disease activity.
Authors: Bhavnit K Bhatia; Jillian W Millsop; Maya Debbaneh; John Koo; Eleni Linos; Wilson Liao Journal: J Am Acad Dermatol Date: 2014-04-26 Impact factor: 11.527
Authors: L Abenavoli; I Proietti; L Leggio; A Ferrulli; L Vonghia; R Capizzi; M Rotoli; P L Amerio; G Gasbarrini; G Addolorato Journal: World J Gastroenterol Date: 2006-02-14 Impact factor: 5.742
Authors: Daniel Pietrzak; Aldona Pietrzak; Dorota Krasowska; Andrzej Borzęcki; Kinga Franciszkiewicz-Pietrzak; Beata Polkowska-Pruszyńska; Maja Baranowska; Kristian Reich Journal: Arch Dermatol Res Date: 2017-09-13 Impact factor: 3.017