Literature DB >> 15491290

Prognostic significance of hepatocyte growth factor and c-MET expression in patients with diffuse large B-cell lymphoma.

R Kawano1, K Ohshima, K Karube, T Yamaguchi, S Kohno, J Suzumiya, M Kikuchi, K Tamura.   

Abstract

The expression and prognostic significance of hepatocyte growth factor (HGF) and its receptor c-MET (MET proto-oncogene) was analysed in 96 cases of diffuse large B-cell lymphoma (DLBCL). Tissue sections were immunohistochemically stained for HGF and c-Met. The prognosis of HGF-positive and c-Met-positive cases was significantly worse than negative cases (HGF: P = 0.0036; c-Met: P = 0.0002). In addition, in the low-risk international prognostic index group, HGF-negative and c-Met-negative cases had a significantly better prognosis than positive cases (HGF: P = 0.0009; c-Met: P < 0.0001). Our results suggest that HGF/c-MET is a useful clinical marker of prognosis for patients with DLBCL.

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Year:  2004        PMID： 15491290     DOI： 10.1111/j.1365-2141.2004.05197.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  8 in total

1.  HDAC6 regulates microRNA-27b that suppresses proliferation, promotes apoptosis and target MET in diffuse large B-cell lymphoma.

Authors:  Y J Jia; Z B Liu; W G Wang; C B Sun; P Wei; Y L Yang; M J You; B H Yu; X Q Li; X Y Zhou
Journal:  Leukemia       Date:  2017-09-28       Impact factor: 11.528

2.  Expression of the c-Met oncogene by tumor cells predicts a favorable outcome in classical Hodgkin's lymphoma.

Authors:  Chuanhui Xu; Wouter Plattel; Anke van den Berg; Nele Rüther; Xin Huang; Miao Wang; Debora de Jong; Hans Vos; Gustaaf van Imhoff; Andreas Viardot; Peter Möller; Sibrand Poppema; Arjan Diepstra; Lydia Visser
Journal:  Haematologica       Date:  2011-12-16       Impact factor: 9.941

3.  Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphoma.

Authors:  Lu Dai; Jimena Trillo-Tinoco; Yueyu Cao; Karlie Bonstaff; Lisa Doyle; Luis Del Valle; Denise Whitby; Chris Parsons; Krzysztof Reiss; Jovanny Zabaleta; Zhiqiang Qin
Journal:  Blood       Date:  2015-11-03       Impact factor: 22.113

4.  CD163 and c-Met expression in the lymph node and the correlations between elevated levels of serum free light chain and the different clinicopathological parameters of advanced classical Hodgkin's lymphoma.

Authors:  Magdy Bedewy; Shereen El-Maghraby; Ahmed Bedewy
Journal:  Blood Res       Date:  2013-06-25

Review 5.  The role of HGF/c-MET signaling pathway in lymphoma.

Authors:  Bao Quoc Lam; Lu Dai; Zhiqiang Qin
Journal:  J Hematol Oncol       Date:  2016-12-07       Impact factor: 17.388

6.  Aberrant localization of apoptosis protease activating factor-1 in lipid raft sub-domains of diffuse large B cell lymphomas.

Authors:  Jayshree L Hirpara; Thomas Loh; Siok Bian Ng; Wee Joo Chng; Shazib Pervaiz
Journal:  Oncotarget       Date:  2016-12-20

7.  Mucin 20 modulates proteasome capacity through c-Met signalling to increase carfilzomib sensitivity in mantle cell lymphoma.

Authors:  Xiaobin Wang; Fazal Shirazi; Wei Yan; Xiaoyu Liu; Hua Wang; Robert Z Orlowski; Huihan Wang
Journal:  J Cell Mol Med       Date:  2021-10-14       Impact factor: 5.310

8.  High MET gene copy number predicted poor prognosis in primary intestinal diffuse large B-cell lymphoma.

Authors:  Wan-Ting Huang; Shih-Sung Chuang
Journal:  Diagn Pathol       Date:  2013-02-04       Impact factor: 2.644
  8 in total

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