| Literature DB >> 15490318 |
P Bremner1, S Tang, H Birkmayer, B L Fiebich, E Muñoz, N Marquez, D Rivera, M Heinrich.
Abstract
Two phenylpropanoids from Bupleurum fruticosum (Apiaceae/Umbelliferae) were shown to inhibit the transcriptional activity induced by PMA or TNFalpha of an NF-kappaB-controlled reporter gene. Western blot experiments indicated that the phenylpropanoids did not prevent IkappaBalpha degradation, suggesting that their molecular target is at a post-IKB degradation level. Both compounds prevented cytokine (IL-1, IL-6, TNF, IL-8) release and prostaglandin E2 synthesis.Entities:
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Year: 2004 PMID： 15490318 DOI： 10.1055/s-2004-832616
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352