Literature DB >> 15490317

HPLC-based activity profiling of Salvia miltiorrhiza for MAO A and iNOS inhibitory activities.

Kathrin Dittmann1, Clarissa Gerhäuser, Karin Klimo, Matthias Hamburger.   

Abstract

In the course of a screening of plant extracts for potential CNS and anti-inflammatory activities, a dichloromethane extract of Salvia miltiorrhiza showed a pronounced inhibitory effect on recombinant monoamine oxidase A (MAO A) and on inducible NO synthase (iNOS) induction in Raw 267.4 cells. With the aid of HPLC-based profiling techniques, activities could be linked, to a significant extent, to peaks of tanshinone-type diterpenoids, four of which were subsequently isolated. The IC50 of the most active compound, 15,16-dihydrotanshinone I, on human recombinant MAO A was at 23 microM, and 2.4 microM on lipopolysaccharide-mediated iNOS induction in Raw 267.4 cells.

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Year:  2004        PMID： 15490317     DOI： 10.1055/s-2004-832615

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  6 in total

1.  Identification of GABA A receptor modulators in Kadsura longipedunculata and assignment of absolute configurations by quantum-chemical ECD calculations.

Authors:  Janine Zaugg; Samad Nejad Ebrahimi; Martin Smiesko; Igor Baburin; Steffen Hering; Matthias Hamburger
Journal:  Phytochemistry       Date:  2011-08-31       Impact factor: 4.072

2.  Positive GABA(A) receptor modulators from Acorus calamus and structural analysis of (+)-dioxosarcoguaiacol by 1D and 2D NMR and molecular modeling.

Authors:  Janine Zaugg; Eva Eickmeier; Samad Nejad Ebrahimi; Igor Baburin; Steffen Hering; Matthias Hamburger
Journal:  J Nat Prod       Date:  2011-05-12       Impact factor: 4.050

Review 3.  Natural Products Inhibitors of Monoamine Oxidases-Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma.

Authors:  Narayan D Chaurasiya; Francisco Leon; Ilias Muhammad; Babu L Tekwani
Journal:  Molecules       Date:  2022-07-04       Impact factor: 4.927

4.  HPLC-based activity profiling: discovery of piperine as a positive GABA(A) receptor modulator targeting a benzodiazepine-independent binding site.

Authors:  Janine Zaugg; Igor Baburin; Barbara Strommer; Hyun-Jung Kim; Steffen Hering; Matthias Hamburger
Journal:  J Nat Prod       Date:  2010-02-26       Impact factor: 4.050

5.  HPLC-based activity profiling approach for the discovery of GABAA receptor ligands using an automated two microelectrode voltage clamp assay on Xenopus oocytes.

Authors:  Hyun Jung Kim; Igor Baburin; Sophia Khom; Steffen Hering; Matthias Hamburger
Journal:  Planta Med       Date:  2008-04       Impact factor: 3.352

6.  HPLC-based activity profiling for GABAA receptor modulators from the traditional Chinese herbal drug Kushen (Sophora flavescens root).

Authors:  Xinzhou Yang; Igor Baburin; Inken Plitzko; Steffen Hering; Matthias Hamburger
Journal:  Mol Divers       Date:  2011-01-05       Impact factor: 2.943
  6 in total

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