Literature DB >> 15490285

Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese.

Hajime Nawata1, Senji Shirasawa2, Naoki Nakashima3, Eiichi Araki4, Jun Hashiguchi5, Seibei Miyake6, Teruaki Yamauchi7, Kazuyuki Hamaguchi8, Hironobu Yoshimatsu8, Haruo Takeda9, Hideo Fukushima10, Takayuki Sasahara11, Kohei Yamaguchi12, Noriyuki Sonoda1, Tomoko Sonoda13, Masahiro Matsumoto14, Yoshiya Tanaka15, Hidekatsu Sugimoto16, Hirotaka Tsubouchi1, Toyoshi Inoguchi1, Toshihiko Yanase1, Nakayasu Wake17, Kenziro Narazaki18, Takashi Eto1, Fumio Umeda19, Mitsuhiro Nakazaki20, Junko Ono21, Takashi Asano22, Yasuko Ito23, Shoichi Akazawa24, Iwaho Hazegawa25, Nobuyuki Takasu26, Moritsugu Shinohara27, Takeshi Nishikawa4, Seiho Nagafuchi28, Toshimitsu Okeda29, Katsumi Eguchi30, Masanori Iwase31, Mayuko Ishikawa2, Masayuki Aoki32, Naoto Keicho33, Norihiro Kato33, Kazuki Yasuda33, Ken Yamamoto32, Takehiko Sasazuki34.   

Abstract

Type 2 diabetes mellitus is a heterogeneous disorder, and the development of type 2 diabetes mellitus is associated with both insulin secretion defect and insulin resistance. The primary metabolic defect leading to type 2 diabetes mellitus has been thought to be varied among populations, especially in Japanese and Caucasians. Here, we have done the genome-wide scan for type 2 diabetes mellitus using 102 affected Japanese sib-pairs to identify the genetic factors predisposing to type 2 diabetes mellitus. Nonparametric linkage analysis showed one suggestive evidence for linkage to 11p13-p12 [D11S905: two-point maximum LOD score (MLS) of 2.89 and multipoint MLS of 2.32] and one nominally significant evidence for linkage to 6q15-q16 (D6S462: two-point MLS of 2.02). Interestingly, the 11p13-p12 region was reported to be a susceptibility locus for Japanese type 2 diabetes mellitus with suggestive evidence of linkage, and D11S905 was within 5 cM to D11S935 with the highest MLS in the previous linkage analysis reported. The only overlapped susceptibility region with suggestive evidence of linkage for Japanese type 2 diabetes mellitus was D11S935-D11S905 among the three reports including this study. These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12.

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Year:  2004        PMID： 15490285     DOI： 10.1007/s10038-004-0199-3

Source DB:  PubMed          Journal:  J Hum Genet        ISSN： 1434-5161            Impact factor:   3.172


  11 in total

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Authors:  Gonçalo R Abecasis; Stacey S Cherny; William O Cookson; Lon R Cardon
Journal:  Nat Genet       Date:  2001-12-03       Impact factor: 38.330

2.  Mapping genes influencing type 2 diabetes risk and BMI in Japanese subjects.

Authors:  Naoko Iwasaki; Nancy J Cox; Yan-Qing Wang; Peter E H Schwarz; Graeme I Bell; Masashi Honda; Mitsuo Imura; Makiko Ogata; Masayuki Saito; Naoyuki Kamatani; Yasuhiko Iwamoto
Journal:  Diabetes       Date:  2003-01       Impact factor: 9.461

3.  Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese.

Authors:  K Sakai; S Shirasawa; N Ishikawa; K Ito; H Tamai; K Kuma; T Akamizu; M Tanimura; K Furugaki; K Yamamoto; T Sasazuki
Journal:  Hum Mol Genet       Date:  2001-06-15       Impact factor: 6.150

4.  A full genome scan for gastric cancer.

Authors:  M Aoki; K Yamamoto; H Noshiro; K Sakai; J Yokota; T Kohno; T Tokino; S Ishida; S Ohyama; I Ninomiya; K Uesaka; M Kitajima; S Shimada; S Matsuno; M Yano; M Hiratsuka; H Sugimura; F Itoh; T Minamoto; Y Maehara; S Takenoshita; T Aikou; H Katai; K Yoshimura; T Takahashi; K Akagi; M Sairenji; Y Yamamura; T Sasazuki
Journal:  J Med Genet       Date:  2005-01       Impact factor: 6.318

5.  Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus.

Authors: 
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Review 6.  Global and societal implications of the diabetes epidemic.

Authors:  P Zimmet; K G Alberti; J Shaw
Journal:  Nature       Date:  2001-12-13       Impact factor: 49.962

7.  Risk factors for worsening to diabetes in subjects with impaired glucose tolerance.

Authors:  T Kadowaki; Y Miyake; R Hagura; Y Akanuma; H Kajinuma; N Kuzuya; F Takaku; K Kosaka
Journal:  Diabetologia       Date:  1984-01       Impact factor: 10.122

8.  Genomewide search for type 2 diabetes susceptibility genes in four American populations.

Authors:  M G Ehm; M C Karnoub; H Sakul; K Gottschalk; D C Holt; J L Weber; D Vaske; D Briley; L Briley; J Kopf; P McMillen; Q Nguyen; M Reisman; E H Lai; G Joslyn; N S Shepherd; C Bell; M J Wagner; D K Burns
Journal:  Am J Hum Genet       Date:  2000-05-02       Impact factor: 11.025

9.  Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study.

Authors:  B C Martin; J H Warram; A S Krolewski; R N Bergman; J S Soeldner; C R Kahn
Journal:  Lancet       Date:  1992-10-17       Impact factor: 79.321

10.  Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p.

Authors:  Yasumichi Mori; Shuichi Otabe; Christian Dina; Kazuki Yasuda; Céline Populaire; Cécile Lecoeur; Vincent Vatin; Emmanuelle Durand; Kazuo Hara; Terumasa Okada; Kazuyuki Tobe; Philippe Boutin; Takashi Kadowaki; Philippe Froguel
Journal:  Diabetes       Date:  2002-04       Impact factor: 9.461
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  10 in total

1.  Agreement among type 2 diabetes linkage studies but a poor correlation with results from genome-wide association studies.

Authors:  S Lillioja; A Wilton
Journal:  Diabetologia       Date:  2009-03-19       Impact factor: 10.122

2.  Effect of +36T>C in intron 1 on the glutamine: fructose-6-phosphate amidotransferase 1 gene and its contribution to type 2 diabetes in different populations.

Authors:  Kiyoshi Kunika; Toshihito Tanahashi; Eiji Kudo; Noriko Mizusawa; Eiichiro Ichiishi; Naoto Nakamura; Toshikazu Yoshikawa; Takashi Yamaoka; Hiroaki Yasumo; Kazue Tsugawa; Maki Moritani; Hiroshi Inoue; Mitsuo Itakura
Journal:  J Hum Genet       Date:  2006-09-26       Impact factor: 3.172

3.  Association study on chromosome 20q11.21-13.13 locus and its contribution to type 2 diabetes susceptibility in Japanese.

Authors:  Toshihito Tanahashi; Dai Osabe; Kyoko Nomura; Shuichi Shinohara; Hitoshi Kato; Eiichiro Ichiishi; Naoto Nakamura; Toshikazu Yoshikawa; Yoichiro Takata; Tatsuro Miyamoto; Hiroshi Shiota; Parvaneh Keshavarz; Yuka Yamaguchi; Kiyoshi Kunika; Maki Moritani; Hiroshi Inoue; Mitsuo Itakura
Journal:  Hum Genet       Date:  2006-09-06       Impact factor: 4.132

4.  Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China.

Authors:  Y Liu; D Z Zhou; D Zhang; Z Chen; T Zhao; Z Zhang; M Ning; X Hu; Y F Yang; Z F Zhang; L Yu; L He; H Xu
Journal:  Diabetologia       Date:  2009-05-12       Impact factor: 10.122

5.  KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population.

Authors:  Zhong Chen; Quanzhong Yin; Genshan Ma; Qi Qian
Journal:  Cardiovasc Diabetol       Date:  2010-08-11       Impact factor: 9.951

6.  Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population.

Authors:  Zhong Chen; Xiaofeng Zhang; Genshan Ma; Qi Qian; Yuyu Yao
Journal:  Mol Biol Rep       Date:  2009-07-03       Impact factor: 2.316

Review 7.  Identification of shared genetic susceptibility locus for coronary artery disease, type 2 diabetes and obesity: a meta-analysis of genome-wide studies.

Authors:  Chaoneng Wu; Yunguo Gong; Jie Yuan; Hui Gong; Yunzeng Zou; Junbo Ge
Journal:  Cardiovasc Diabetol       Date:  2012-06-14       Impact factor: 9.951

8.  Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes.

Authors:  Nicki Tiffin; Euan Adie; Frances Turner; Han G Brunner; Marc A van Driel; Martin Oti; Nuria Lopez-Bigas; Christos Ouzounis; Carolina Perez-Iratxeta; Miguel A Andrade-Navarro; Adebowale Adeyemo; Mary Elizabeth Patti; Colin A M Semple; Winston Hide
Journal:  Nucleic Acids Res       Date:  2006-06-06       Impact factor: 16.971

9.  Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.

Authors:  Fumihiko Takeuchi; Masakuni Serizawa; Ken Yamamoto; Tomomi Fujisawa; Eitaro Nakashima; Keizo Ohnaka; Hiroshi Ikegami; Takao Sugiyama; Tomohiro Katsuya; Makoto Miyagishi; Naoki Nakashima; Hajime Nawata; Jiro Nakamura; Suminori Kono; Ryoichi Takayanagi; Norihiro Kato
Journal:  Diabetes       Date:  2009-04-28       Impact factor: 9.461

10.  Lack of association of genetic variation in chromosome region 15q14-22.1 with type 2 diabetes in a Japanese population.

Authors:  Yuka Yamaguchi; Maki Moritani; Toshihito Tanahashi; Dai Osabe; Kyoko Nomura; Yuka Fujita; Parvaneh Keshavarz; Kiyoshi Kunika; Naoto Nakamura; Toshikazu Yoshikawa; Eiichiro Ichiishi; Hiroshi Shiota; Natsuo Yasui; Hiroshi Inoue; Mitsuo Itakura
Journal:  BMC Med Genet       Date:  2008-03-27       Impact factor: 2.103
  10 in total

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