Literature DB >> 15489952

Superoxide production by phagocytic leukocytes: the scientific legacy of Bernard Babior.

John T Curnutte.   

Abstract

It was 32 years ago that Bernard Babior, Ruby Kipnes, and I submitted a paper to the JCI reporting that polymorphonuclear leukocytes produce superoxide (O(2) (-)) during phagocytosis and that this highly reactive oxygen radical might function as a microbicidal agent. The story of how our lab came to this discovery is one of a special relationship between a student and his brilliant mentor.

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Year:  2004        PMID: 15489952      PMCID: PMC522274          DOI: 10.1172/JCI23377

Source DB:  PubMed          Journal:  J Clin Invest        ISSN: 0021-9738            Impact factor:   14.808


  16 in total

1.  Detection of free radicals generated during enzymic oxidations by the initiation of sulfite oxidation.

Authors:  I FRIDOVICH; P HANDLER
Journal:  J Biol Chem       Date:  1961-06       Impact factor: 5.157

2.  Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent.

Authors:  B M Babior; R S Kipnes; J T Curnutte
Journal:  J Clin Invest       Date:  1973-03       Impact factor: 14.808

3.  The generation of superoxide radical during the autoxidation of hemoglobin.

Authors:  H P Misra; I Fridovich
Journal:  J Biol Chem       Date:  1972-11-10       Impact factor: 5.157

4.  Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).

Authors:  J M McCord; I Fridovich
Journal:  J Biol Chem       Date:  1969-11-25       Impact factor: 5.157

5.  An enzyme-based theory of obligate anaerobiosis: the physiological function of superoxide dismutase.

Authors:  J M McCord; B B Keele; I Fridovich
Journal:  Proc Natl Acad Sci U S A       Date:  1971-05       Impact factor: 11.205

6.  Quantitative leukocyte iodination.

Authors:  S H Pincus; S J Klebanoff
Journal:  N Engl J Med       Date:  1971-04-08       Impact factor: 91.245

7.  Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function.

Authors:  B Holmes; A R Page; R A Good
Journal:  J Clin Invest       Date:  1967-09       Impact factor: 14.808

8.  Investigating antibody-catalyzed ozone generation by human neutrophils.

Authors:  Bernard M Babior; Cindy Takeuchi; Julie Ruedi; Abel Gutierrez; Paul Wentworth
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-24       Impact factor: 11.205

9.  Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection.

Authors:  R I Lehrer; M J Cline
Journal:  J Clin Invest       Date:  1969-08       Impact factor: 14.808

10.  Iodination of bacteria: a bactericidal mechanism.

Authors:  S J Klebanoff
Journal:  J Exp Med       Date:  1967-12-01       Impact factor: 14.307

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