| Literature DB >> 15489167 |
Gabriele Weitnauer1, Gerd Hauser, Carsten Hofmann, Ulrike Linder, Raija Boll, Klaus Pelz, Steffen J Glaser, Andreas Bechthold.
Abstract
The oligosaccharide antibiotics avilamycin A and C are produced by Streptomyces viridochromogenes Tu57. Both consist of a heptasaccharide chain, which is attached to a polyketide-derived dichloroisoeverninic acid moiety. They show excellent antibiotic activity against Gram-positive bacteria. Both molecules are modified by O-methylation at different positions, which contributes to poor water solubility and difficulties in galenical drug development. In order to generate novel avilamycin derivatives with improved polarity and improved pharmacokinetic properties, we generated a series of mutants with one, two, or three mutated methyltransferase genes. Based on the structure of the novel avilamycin derivatives, the exact function of three methyltransferases, AviG2, AviG5, and AviG6, involved in avilamycin biosynthesis could be assigned.Entities:
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Year: 2004 PMID： 15489167 DOI： 10.1016/j.chembiol.2004.08.016
Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521