PURPOSE: Higher baseline pattern standard deviation (PSD) and larger vertical cup-to-disk ratio (VC/D) were factors in the predictive model for the development of primary open-angle glaucoma (POAG) in the Ocular Hypertension Treatment Study. Because early changes in PSD and VC/D may be indicative of early POAG damage, we repeated the prediction model excluding PSD and VC/D. DESIGN: Reanalysis of baseline factors for the development of POAG. METHODS: We compared the hazard ratios for baseline factors predictive of POAG in the multivariate Cox proportional hazards model that included PSD and VC/D and in the model that excluded them. RESULTS: Hazard ratios for baseline factors predictive of POAG in Ocular Hypertension Treatment Study were not substantially affected by the inclusion or exclusion of PSD and VC/D in the proportional hazards model. CONCLUSION: Whether PSD or VC/D was included in the Cox proportional hazards model, the same baseline factors were statistically significant and their hazard ratios were essentially similar.
PURPOSE: Higher baseline pattern standard deviation (PSD) and larger vertical cup-to-disk ratio (VC/D) were factors in the predictive model for the development of primary open-angle glaucoma (POAG) in the Ocular Hypertension Treatment Study. Because early changes in PSD and VC/D may be indicative of early POAG damage, we repeated the prediction model excluding PSD and VC/D. DESIGN: Reanalysis of baseline factors for the development of POAG. METHODS: We compared the hazard ratios for baseline factors predictive of POAG in the multivariate Cox proportional hazards model that included PSD and VC/D and in the model that excluded them. RESULTS: Hazard ratios for baseline factors predictive of POAG in Ocular Hypertension Treatment Study were not substantially affected by the inclusion or exclusion of PSD and VC/D in the proportional hazards model. CONCLUSION: Whether PSD or VC/D was included in the Cox proportional hazards model, the same baseline factors were statistically significant and their hazard ratios were essentially similar.
Authors: Donald L Budenz; Douglas R Anderson; William J Feuer; Julia A Beiser; Joyce Schiffman; Richard K Parrish; Jody R Piltz-Seymour; Mae O Gordon; Michael A Kass Journal: Ophthalmology Date: 2006-09-25 Impact factor: 12.079
Authors: Katherine I Wilson; Pooja Godara; Jessica V Jasien; Emma Zohner; Jeffrey S Morris; Christopher A Girkin; Brian C Samuels; J Crawford Downs Journal: Invest Ophthalmol Vis Sci Date: 2020-06-03 Impact factor: 4.799
Authors: John E Markert; Daniel C Turner; Jessica V Jasien; Cyril N A Nyankerh; Brian C Samuels; J Crawford Downs Journal: Transl Vis Sci Technol Date: 2022-09-01 Impact factor: 3.048