Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Antagonism of Myc functions by Arf.

Literature DB >> 15488753

Antagonism of Myc functions by Arf.

Abstract

The Arf-Mdm2-p53 tumor suppressor pathway is activated by sustained hyperproliferative signals emanating from oncoproteins such as Myc. A recent study reveals a novel level of feedback control, whereby induced p19(Arf) binds to Myc and blocks cell proliferation by selectively impairing its transactivation functions.

Entities: Disease Gene

Mesh：

Substances：

Year: 2004 PMID： 15488753 DOI： 10.1016/j.ccr.2004.09.020

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

Keyword Cloud
Cited

19 in total

1. Mouse models of cancer as biological filters for complex genomic data.

Authors: Elisa Oricchio; Andrew L Wolfe; Jonathan H Schatz; Konstantinos J Mavrakis; Hans-Guido Wendel
Journal: Dis Model Mech Date: 2010-09-27 Impact factor: 5.758

Review 2. What has senescence got to do with cancer?

Authors: Goberdhan P Dimri
Journal: Cancer Cell Date: 2005-06 Impact factor: 31.743

3. Bidirectional autoregulatory mechanism of metastasis-associated protein 1-alternative reading frame pathway in oncogenesis.

Authors: Da-Qiang Li; Suresh B Pakala; Sirigiri Divijendra Natha Reddy; Kazufumi Ohshiro; Jun-Xiang Zhang; Lei Wang; Yanping Zhang; Ignacio Moreno de Alborán; M Radhakrishna Pillai; Jeyanthy Eswaran; Rakesh Kumar
Journal: Proc Natl Acad Sci U S A Date: 2011-05-09 Impact factor: 11.205

4. Borealin is repressed in response to p53/Rb signaling.

Authors: Dipali A Date; Cara J Jacob; Mike E Bekier; Andrew C Stiff; Mark W Jackson; William R Taylor
Journal: Cell Biol Int Date: 2007-07-15 Impact factor: 3.612

5. Role of the translocation partner in protection against AID-dependent chromosomal translocations.

Authors: Mila Jankovic; Davide F Robbiani; Yair Dorsett; Thomas Eisenreich; Yang Xu; Alexander Tarakhovsky; Andre Nussenzweig; Michel C Nussenzweig
Journal: Proc Natl Acad Sci U S A Date: 2009-12-04 Impact factor: 11.205

6. Linking the p53 tumour suppressor pathway to somatic cell reprogramming.

Authors: Teruhisa Kawamura; Jotaro Suzuki; Yunyuan V Wang; Sergio Menendez; Laura Batlle Morera; Angel Raya; Geoffrey M Wahl; Juan Carlos Izpisúa Belmonte
Journal: Nature Date: 2009-08-09 Impact factor: 49.962

7. Differential p53-independent outcomes of p19(Arf) loss in oncogenesis.

Authors: Zhenbang Chen; Arkaitz Carracedo; Hui-Kuan Lin; Jason A Koutcher; Nille Behrendt; Ainara Egia; Andrea Alimonti; Brett S Carver; William Gerald; Julie Teruya-Feldstein; Massimo Loda; Pier Paolo Pandolfi
Journal: Sci Signal Date: 2009-08-18 Impact factor: 8.192