OBJECTIVE: To detect the presence of estrogen (ER) and progesterone (PR) receptors in endometrial polyps and adjacent endometrium in postmenopausal women. METHODS: Forty-four consecutively enrolled postmenopausal patients were submitted to operative hysteroscopy. These patients had diagnosed benign endometrial polyp. The presence of ER and PR was determined in endometrial samples and polyps by immunohistochemical method and the slides were evaluated using a semiquantitative analysis. RESULTS: In the glandular epithelium, the median of the ER score was 7.0 in the polyps and 5.0 in the endometrium (P<0.0001) and the median of the PR was 6.0 in the polyps and 4.0 in the endometrium (P<0.0001). In the stroma, the median of the ER score was 6.0 in the polyps and 5.0 in the endometrium (P=0.021) and the median of the PR score was 4.0 in the polyps and 4.5 in the endometrium (P=0.34 ). CONCLUSIONS: Our data suggests that steroids receptors present a crucial role in the phisiopathology of the endometrial polyps in postmenopausal women, specially the estrogen receptors.
OBJECTIVE: To detect the presence of estrogen (ER) and progesterone (PR) receptors in endometrial polyps and adjacent endometrium in postmenopausal women. METHODS: Forty-four consecutively enrolled postmenopausal patients were submitted to operative hysteroscopy. These patients had diagnosed benign endometrial polyp. The presence of ER and PR was determined in endometrial samples and polyps by immunohistochemical method and the slides were evaluated using a semiquantitative analysis. RESULTS: In the glandular epithelium, the median of the ER score was 7.0 in the polyps and 5.0 in the endometrium (P<0.0001) and the median of the PR was 6.0 in the polyps and 4.0 in the endometrium (P<0.0001). In the stroma, the median of the ER score was 6.0 in the polyps and 5.0 in the endometrium (P=0.021) and the median of the PR score was 4.0 in the polyps and 4.5 in the endometrium (P=0.34 ). CONCLUSIONS: Our data suggests that steroids receptors present a crucial role in the phisiopathology of the endometrial polyps in postmenopausal women, specially the estrogen receptors.
Authors: Lian Fang; Wang Rui-Xia; Ma Feng-Mei; Sun Zhen-Gao; Wang Li-Hong; Shi Lei Journal: J Altern Complement Med Date: 2012-10-17 Impact factor: 2.579
Authors: Carlo Saccardi; Salvatore Gizzo; Kathrin Ludwig; Maria Guido; Mara Scarton; Michele Gangemi; Raffaele Tinelli; Pietro Salvatore Litta Journal: Biomed Res Int Date: 2013-08-22 Impact factor: 3.411
Authors: Jesus S Jiménez-Lopez; Ana Granado-San Miguel; Alvaro Tejerizo-Garcia; Jose L Muñoz-Gonzalez; Gregorio Lopez-Gonzalez Journal: BMC Womens Health Date: 2015-02-22 Impact factor: 2.809