Literature DB >> 1548783

Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo.

P Westervelt1, D B Trowbridge, L G Epstein, B M Blumberg, Y Li, B H Hahn, G M Shaw, R W Price, L Ratner.   

Abstract

Strains of human immunodeficiency virus type 1 differ in their abilities to infect and replicate in primary human macrophages. Chimeric clones were constructed from a provirus unable to infect macrophages (NLHX) and envelope sequences (V3 loop) of viruses derived without cultivation from brain (YU2 and w1-1c1) or spleen (w2-1b4) tissues. The substituted V3 loop sequences in each case were sufficient to confer upon NLHX the ability to infect macrophages. Furthermore, an envelope domain immediately N terminal to the V3 loop also was found to modulate the level of replication in macrophages. These results demonstrate that an envelope determinant derived directly from patients with AIDS confers HIV-1 tropism for macrophages.

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Year:  1992        PMID： 1548783      PMCID： PMC289061     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  35 in total

1.  The human immunodeficiency virus type 2 vpr gene is essential for productive infection of human macrophages.

Authors:  N Hattori; F Michaels; K Fargnoli; L Marcon; R C Gallo; G Franchini
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

2.  Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytes.

Authors:  P Westervelt; H E Gendelman; L Ratner
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

Review 3.  Neutralization of HIV-1: a paradox of humoral proportions.

Authors:  P L Nara; R R Garrity; J Goudsmit
Journal:  FASEB J       Date:  1991-07       Impact factor: 5.191

4.  Hypothetical assignment of intrachain disulfide bonds for HIV-2 and SIV envelope glycoproteins.

Authors:  J A Hoxie
Journal:  AIDS Res Hum Retroviruses       Date:  1991-06       Impact factor: 2.205

5.  Macrophage-HIV interaction: viral isolation and target cell tropism.

Authors:  H E Gendelman; L M Baca; H Husayni; J A Turpin; D Skillman; D C Kalter; J M Orenstein; D L Hoover; M S Meltzer
Journal:  AIDS       Date:  1990-03       Impact factor: 4.177

6.  Activation of caprine arthritis-encephalitis virus expression during maturation of monocytes to macrophages.

Authors:  O Narayan; S Kennedy-Stoskopf; D Sheffer; D E Griffin; J E Clements
Journal:  Infect Immun       Date:  1983-07       Impact factor: 3.441

7.  Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.

Authors:  S S Hwang; T J Boyle; H K Lyerly; B R Cullen
Journal:  Science       Date:  1991-07-05       Impact factor: 47.728

8.  Macrophage-tropic variants of SIV are associated with specific AIDS-related lesions but are not essential for the development of AIDS.

Authors:  R C Desrosiers; A Hansen-Moosa; K Mori; D P Bouvier; N W King; M D Daniel; D J Ringler
Journal:  Am J Pathol       Date:  1991-07       Impact factor: 4.307

9.  Mutations within the human immunodeficiency virus type 1 gp160 envelope glycoprotein alter its intracellular transport and processing.

Authors:  R L Willey; T Klimkait; D M Frucht; J S Bonifacino; M A Martin
Journal:  Virology       Date:  1991-09       Impact factor: 3.616

10.  Molecular characterization of human immunodeficiency virus type 1 cloned directly from uncultured human brain tissue: identification of replication-competent and -defective viral genomes.

Authors:  Y Li; J C Kappes; J A Conway; R W Price; G M Shaw; B H Hahn
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103
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  132 in total

1.  Distinct human immunodeficiency virus strains in the bone marrow are associated with the development of thrombocytopenia.

Authors:  F Voulgaropoulou; B Tan; M Soares; B Hahn; L Ratner
Journal:  J Virol       Date:  1999-04       Impact factor: 5.103

2.  Effect of soluble CD4 on exposure of epitopes on primary, intact, native human immunodeficiency virus type 1 virions of different genetic clades.

Authors:  H A Mbah; S Burda; M K Gorny; C Williams; K Revesz; S Zolla-Pazner; P N Nyambi
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

3.  Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120.

Authors:  C A Derdeyn; J M Decker; J N Sfakianos; X Wu; W A O'Brien; L Ratner; J C Kappes; G M Shaw; E Hunter
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

4.  Evolution of the human immunodeficiency virus type 1 envelope during infection reveals molecular corollaries of specificity for coreceptor utilization and AIDS pathogenesis.

Authors:  Q X Hu; A P Barry; Z X Wang; S M Connolly; S C Peiper; M L Greenberg
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

5.  A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions.

Authors:  K Gupta; D Ott; T J Hope; R F Siliciano; J D Boeke
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

6.  Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitution.

Authors:  J J De Jong; A De Ronde; W Keulen; M Tersmette; J Goudsmit
Journal:  J Virol       Date:  1992-11       Impact factor: 5.103

7.  Addition of a single gp120 glycan confers increased binding to dendritic cell-specific ICAM-3-grabbing nonintegrin and neutralization escape to human immunodeficiency virus type 1.

Authors:  James Lue; Mayla Hsu; David Yang; Preston Marx; Zhiwei Chen; Cecilia Cheng-Mayer
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

8.  Mutational pathways and genetic barriers to CXCR4-mediated entry by human immunodeficiency virus type 1.

Authors:  Wei Huang; Arne Frantzell; Jonathan Toma; Signe Fransen; Jeannette M Whitcomb; Eric Stawiski; Christos J Petropoulos
Journal:  Virology       Date:  2010-11-10       Impact factor: 3.616

9.  HIV-1 macrophage tropism is determined at multiple levels of the viral replication cycle.

Authors:  R A Fouchier; M Brouwer; N A Kootstra; H G Huisman; H Schuitemaker
Journal:  J Clin Invest       Date:  1994-11       Impact factor: 14.808

10.  Conformational changes affecting the V3 and CD4-binding domains of human immunodeficiency virus type 1 gp120 associated with env processing and with binding of ligands to these sites.

Authors:  A Pinter; W J Honnen; S A Tilley
Journal:  J Virol       Date:  1993-09       Impact factor: 5.103
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