Literature DB >> 15486456

Chemoenzymatic synthesis of diverse asparagine-linked alpha-(2,3)-sialyloligosaccharides.

Kazuhiro Fukae1, Naoki Yamamoto, Yuri Hatakeyama, Yasuhiro Kajihara.   

Abstract

Partial sialyl transfer reaction by alpha-(2,3)-sialyltransferase toward (Gal-beta-1,4-GlcNAc-beta-1,2-Man-alpha-1,6/1,3-)(2)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-asparagine-Fmoc 1 was examined to obtain mono-alpha-(2,3)-sialyloligosaccharides and then branch-specific exo-glycosidase digestion (beta-D-galactosidase, N -acetyl-beta-D-glucosaminidase and alpha-D-mannosidase) toward the asialo-branch was performed to obtain diverse asparagine-linked complex type alpha-(2,3)-sialyloligosaccharides. In addition, two kinds of disialyloligosaccharides in which the sialyl linkage was a mixture of alpha-(2,3)- and alpha-(2,6)-types were also specifically prepared by an additional alpha-(2,6)-sialyltransferase reaction toward mono-alpha-(2,3)-sialyloligosaccharides thus obtained.

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Year:  2004        PMID： 15486456     DOI： 10.1023/B:GLYC.0000045096.89408.50

Source DB:  PubMed          Journal:  Glycoconj J        ISSN： 0282-0080            Impact factor:   2.916


  8 in total

1.  Large-scale expression of recombinant sialyltransferases and comparison of their kinetic properties with native enzymes.

Authors:  M A Williams; H Kitagawa; A K Datta; J C Paulson; J C Jamieson
Journal:  Glycoconj J       Date:  1995-12       Impact factor: 2.916

2.  Cloning of the lipooligosaccharide alpha-2,3-sialyltransferase from the bacterial pathogens Neisseria meningitidis and Neisseria gonorrhoeae.

Authors:  M Gilbert; D C Watson; A M Cunningham; M P Jennings; N M Young; W W Wakarchuk
Journal:  J Biol Chem       Date:  1996-11-08       Impact factor: 5.157

3.  Enzymatic synthesis of a sialyl Lewis X dimer from egg yolk as an inhibitor of E-selectin.

Authors:  C H Lin; M Shimazaki; C H Wong; M Koketsu; L R Juneja; M Kim
Journal:  Bioorg Med Chem       Date:  1995-12       Impact factor: 3.641

4.  Prompt chemoenzymatic synthesis of diverse complex-type oligosaccharides and its application to the solid-phase synthesis of a glycopeptide with Asn-linked sialyl-undeca- and asialo-nonasaccharides.

Authors:  Yasuhiro Kajihara; Yasuhiro Suzuki; Naoki Yamamoto; Ken Sasaki; Tohru Sakakibara; Lekh Raj Juneja
Journal:  Chemistry       Date:  2004-02-20       Impact factor: 5.236

5.  Enzymatic characterization of CMP-NeuAc:Gal beta 1-4GlcNAc-R alpha(2-3)-sialyltransferase from human placenta.

Authors:  M Nemansky; D H van den Eijnden
Journal:  Glycoconj J       Date:  1993-02       Impact factor: 2.916

6.  Human liver and human placenta both contain CMP-NeuAc:Gal beta 1-->4GlcNAc-R alpha 2-->3- as well as alpha 2-->6-sialyltransferase activity.

Authors:  M Nemansky; W E Schiphorst; C A Koeleman; D H Van den Eijnden
Journal:  FEBS Lett       Date:  1992-11-02       Impact factor: 4.124

7.  Branch specificity of bovine colostrum CMP-sialic acid: N-acetyllactosaminide alpha 2----6-sialyltransferase. Interaction with biantennary oligosaccharides and glycopeptides of N-glycosylproteins.

Authors:  D H Joziasse; W E Schiphorst; D H van den Eijnden; J A van Kuik; H van Halbeek; J F Vliegenthart
Journal:  J Biol Chem       Date:  1985-01-25       Impact factor: 5.157

Review 8.  Biological roles of oligosaccharides: all of the theories are correct.

Authors:  A Varki
Journal:  Glycobiology       Date:  1993-04       Impact factor: 4.313
  8 in total
  1 in total

Review 1.  Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update for 2003-2004.

Authors:  David J Harvey
Journal:  Mass Spectrom Rev       Date:  2009 Mar-Apr       Impact factor: 10.946
  1 in total

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