BACKGROUND: Inflammatory mediators participate in the pathogenesis and pathophysiology of skin disease (e.g. eczema). Although some investigators have suggested that serotonin may participate in the eczematous process, there has been little substantial evidence. Our objective was to study further the participation of serotonin in the pathogenesis of chronic eczema. METHODS: Immunohistochemical techniques were used to study the expression of serotonin in the lesions of patients with chronic eczema. RESULTS: There was a significantly stronger expression of serotonin in the prickle cells, sweat gland cells, sebaceous gland cells, and hair roots of the lesions in patients with chronic eczema. There was no positive expression of serotonin in normal skin. CONCLUSIONS: Serotonin is probably important in the pathogenesis of chronic eczema. We demonstrated alterations in the expression of serotonin in chronic eczema lesions, which may in turn provide new insight into the pathogenesis of chronic eczema. Serotonin, along with cytokines, T lymphocytes, B lymphocytes, and macrophages, participates in the immune response and influences the inflammatory process by means of keratinocytes.
BACKGROUND: Inflammatory mediators participate in the pathogenesis and pathophysiology of skin disease (e.g. eczema). Although some investigators have suggested that serotonin may participate in the eczematous process, there has been little substantial evidence. Our objective was to study further the participation of serotonin in the pathogenesis of chronic eczema. METHODS: Immunohistochemical techniques were used to study the expression of serotonin in the lesions of patients with chronic eczema. RESULTS: There was a significantly stronger expression of serotonin in the prickle cells, sweat gland cells, sebaceous gland cells, and hair roots of the lesions in patients with chronic eczema. There was no positive expression of serotonin in normal skin. CONCLUSIONS:Serotonin is probably important in the pathogenesis of chronic eczema. We demonstrated alterations in the expression of serotonin in chronic eczema lesions, which may in turn provide new insight into the pathogenesis of chronic eczema. Serotonin, along with cytokines, T lymphocytes, B lymphocytes, and macrophages, participates in the immune response and influences the inflammatory process by means of keratinocytes.
Authors: Takeshi Morita; Shannan P McClain; Lyn M Batia; Maurizio Pellegrino; Sarah R Wilson; Michael A Kienzler; Kyle Lyman; Anne Sofie Braun Olsen; Justin F Wong; Cheryl L Stucky; Rachel B Brem; Diana M Bautista Journal: Neuron Date: 2015-06-11 Impact factor: 17.173