Lei Kong1, Nn Santiago, Tian-Quan Han, Sheng-Dao Zhang. 1. Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai Institute of Digestive Surgery, 197 Ruijin II Road, Shanghai 200025, China.
Abstract
AIM: To investigate the clinical characteristics and prognostic factors of a consecutive series of patients with severe acute pancreatitis (SAP). METHODS: Clinical data of SAP patients admitted to our hospital from January 2003 to January 2004 were retrospectively reviewed. Collected data included the age, gender, etiology, length of hospitalization, APACHE II score at admission, local and organ/systemic complications of the patients. RESULTS: Of the 268 acute pancreatitis patients, 94 developed SAP. The mean age of SAP patients was 52 years, the commonest etiology was cholelithiasis (45.7%), the mean length of hospitalization was 70 d, the mean score of APACHE II was 7.7. Fifty-four percent of the patients developed necrosis, 25% abscess, 58% organ/systemic failure. A total of 23.4% (22/94) of the SAP patients died. Respiratory failure was the most common organ dysfunction (90.9%) in deceased SAP patients, followed by cardiovascular failure (86.4%), renal failure (50.0%). In the SAP patients, 90.9% (20/22) developed multiple organ/systemic failures. There were significant differences in age, length of hospitalization, APACHE II score and incidences of respiratory failure, renal failure, cardiovascular failure and hematological failure between deceased SAP patients and survived SAP patients. By multivariate logistic regression analysis, independent prognostic factors for mortality were respiratory failure, cardiovascular failure and renal failure. CONCLUSION: SAP patients are characterized by advanced age, high APACHE II score, organ failure and their death is mainly due to multiple organ/systemic failures. In patients with SAP, respiratory, cardiovascular and renal failures can predict the fatal outcome and more attention should be paid to their clinical evaluation.
AIM: To investigate the clinical characteristics and prognostic factors of a consecutive series of patients with severe acute pancreatitis (SAP). METHODS: Clinical data of SAPpatients admitted to our hospital from January 2003 to January 2004 were retrospectively reviewed. Collected data included the age, gender, etiology, length of hospitalization, APACHE II score at admission, local and organ/systemic complications of the patients. RESULTS: Of the 268 acute pancreatitispatients, 94 developed SAP. The mean age of SAPpatients was 52 years, the commonest etiology was cholelithiasis (45.7%), the mean length of hospitalization was 70 d, the mean score of APACHE II was 7.7. Fifty-four percent of the patients developed necrosis, 25% abscess, 58% organ/systemic failure. A total of 23.4% (22/94) of the SAPpatients died. Respiratory failure was the most common organ dysfunction (90.9%) in deceased SAPpatients, followed by cardiovascular failure (86.4%), renal failure (50.0%). In the SAPpatients, 90.9% (20/22) developed multiple organ/systemic failures. There were significant differences in age, length of hospitalization, APACHE II score and incidences of respiratory failure, renal failure, cardiovascular failure and hematological failure between deceased SAPpatients and survived SAPpatients. By multivariate logistic regression analysis, independent prognostic factors for mortality were respiratory failure, cardiovascular failure and renal failure. CONCLUSION:SAPpatients are characterized by advanced age, high APACHE II score, organ failure and their death is mainly due to multiple organ/systemic failures. In patients with SAP, respiratory, cardiovascular and renal failures can predict the fatal outcome and more attention should be paid to their clinical evaluation.
Authors: G Talamini; C Bassi; M Falconi; N Sartori; L Frulloni; V Di Francesco; S Vesentini; P Pederzoli; G Cavallini Journal: Int J Pancreatol Date: 1996-02
Authors: Kimmo I Halonen; Ville Pettilä; Ari K Leppäniemi; Esko A Kemppainen; Pauli A Puolakkainen; Reijo K Haapiainen Journal: Crit Care Med Date: 2002-06 Impact factor: 7.598
Authors: Ivan Maria Smoday; Igor Petrovic; Luka Kalogjera; Hrvoje Vranes; Helena Zizek; Ivan Krezic; Slaven Gojkovic; Ivan Skorak; Klaudija Hriberski; Ivan Brizic; Milovan Kubat; Sanja Strbe; Ivan Barisic; Marija Sola; Eva Lovric; Marin Lozic; Alenka Boban Blagaic; Anita Skrtic; Sven Seiwerth; Predrag Sikiric Journal: Biomedicines Date: 2022-06-01