OBJECTIVE: SMA1 mice carry a missense mutation in the growth hormone gene that leads to semidominant dwarfism and obesity. In this study, the basic thermal and metabolic properties of SMA1 mice were examined to detect metabolic alterations that can support the accretion of excess fat. RESEARCH METHODS AND PROCEDURES: Basal and resting metabolic rates (RMRs) in wild-type and SMA1 (sma1/+ and sma1/sma1) mice were determined by indirect calorimetry. Body temperature (T(b)) was recorded using intraperitoneally implanted temperature-sensitive transmitters, and body composition was determined by DXA. RESULTS: SMA1 mice have proportionally lower basal and resting metabolic rates, higher body mass (BM)-specific RMRs, and a higher lower critical temperature, and display a decrease in T(b) by 0.4 degrees C in sma1/+ and 0.9 degrees C in sma1/sma1. DISCUSSION: The analysis of gene effects on BM and energy expenditure in mouse mutants must consider the appropriate allometric relationship between BM and metabolic rate. With the exception of T(b), all metabolic alterations observed in SMA1 reflect reduced size.
OBJECTIVE: SMA1 mice carry a missense mutation in the growth hormone gene that leads to semidominant dwarfism and obesity. In this study, the basic thermal and metabolic properties of SMA1 mice were examined to detect metabolic alterations that can support the accretion of excess fat. RESEARCH METHODS AND PROCEDURES: Basal and resting metabolic rates (RMRs) in wild-type and SMA1 (sma1/+ and sma1/sma1) mice were determined by indirect calorimetry. Body temperature (T(b)) was recorded using intraperitoneally implanted temperature-sensitive transmitters, and body composition was determined by DXA. RESULTS: SMA1 mice have proportionally lower basal and resting metabolic rates, higher body mass (BM)-specific RMRs, and a higher lower critical temperature, and display a decrease in T(b) by 0.4 degrees C in sma1/+ and 0.9 degrees C in sma1/sma1. DISCUSSION: The analysis of gene effects on BM and energy expenditure in mouse mutants must consider the appropriate allometric relationship between BM and metabolic rate. With the exception of T(b), all metabolic alterations observed in SMA1 reflect reduced size.
Authors: Carola W Meyer; Juliane Neubronner; Jan Rozman; Gabi Stumm; Andreas Osanger; Claudia Stoeger; Martin Augustin; Johannes Grosse; Martin Klingenspor; Gerhard Heldmaier Journal: J Comp Physiol B Date: 2006-09-29 Impact factor: 2.200
Authors: Karl J Kaiyala; Gregory J Morton; Brian G Leroux; Kayoko Ogimoto; Brent Wisse; Michael W Schwartz Journal: Diabetes Date: 2010-04-22 Impact factor: 9.461
Authors: Keertik Fulzele; Forest Lai; Christopher Dedic; Vaibhav Saini; Yuhei Uda; Chao Shi; Padrig Tuck; Jenna L Aronson; Xiaolong Liu; Jordan M Spatz; Marc N Wein; Paola Divieti Pajevic Journal: J Bone Miner Res Date: 2017-01-05 Impact factor: 6.741
Authors: Helmut Fuchs; Valérie Gailus-Durner; Susanne Neschen; Thure Adler; Luciana Caminha Afonso; Juan Antonio Aguilar-Pimentel; Lore Becker; Alexander Bohla; Julia Calzada-Wack; Christian Cohrs; Anna Dewert; Barbara Fridrich; Lillian Garrett; Lisa Glasl; Alexander Götz; Wolfgang Hans; Sabine M Hölter; Marion Horsch; Anja Hurt; Eva Janas; Dirk Janik; Melanie Kahle; Martin Kistler; Tanja Klein-Rodewald; Christoph Lengger; Tonia Ludwig; Holger Maier; Susan Marschall; Kateryna Micklich; Gabriele Möller; Beatrix Naton; Cornelia Prehn; Oliver Puk; Ildikó Rácz; Michael Räss; Birgit Rathkolb; Jan Rozman; Markus Scheerer; Evelyn Schiller; Anja Schrewe; Ralph Steinkamp; Claudia Stöger; Minxuan Sun; Wilfried Szymczak; Irina Treise; Ingrid Liliana Vargas Panesso; Alexandra M Vernaleken; Monja Willershäuser; Annemarie Wolff-Muscate; Ramona Zeh; Jerzy Adamski; Johannes Beckers; Raffi Bekeredjian; Dirk H Busch; Oliver Eickelberg; Jack Favor; Jochen Graw; Heinz Höfler; Christoph Höschen; Hugo Katus; Martin Klingenspor; Thomas Klopstock; Frauke Neff; Markus Ollert; Holger Schulz; Tobias Stöger; Eckhard Wolf; Wolfgang Wurst; Ali Önder Yildirim; Andreas Zimmer; Martin Hrabě de Angelis Journal: Mamm Genome Date: 2012-08-29 Impact factor: 2.957
Authors: Viola Nordström; Monja Willershäuser; Silke Herzer; Jan Rozman; Oliver von Bohlen Und Halbach; Sascha Meldner; Ulrike Rothermel; Sylvia Kaden; Fabian C Roth; Clemens Waldeck; Norbert Gretz; Martin Hrabě de Angelis; Andreas Draguhn; Martin Klingenspor; Hermann-Josef Gröne; Richard Jennemann Journal: PLoS Biol Date: 2013-03-12 Impact factor: 8.029