Literature DB >> 15482944

Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation.

Thomas Doundoulakis1, Alan X Xiang, Ricardo Lira, Konstantinos A Agrios, Stephen E Webber, Wes Sisson, Robert M Aust, Amit M Shah, Richard E Showalter, James R Appleman, Klaus B Simonsen.   

Abstract

A series of myxopyronin B analogs has been prepared via a convergent synthetic route and were tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against E. coli and S. aureus. The parent lead compound proved to be very sensitive to even small changes. Only the achiral desmethyl myxopyronin B (1a) provided enhanced potency.

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Year:  2004        PMID： 15482944     DOI： 10.1016/j.bmcl.2004.08.045

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Molecular genetic and structural modeling studies of Staphylococcus aureus RNA polymerase and the fitness of rifampin resistance genotypes in relation to clinical prevalence.

Authors:  A J O'Neill; T Huovinen; C W G Fishwick; I Chopra
Journal:  Antimicrob Agents Chemother       Date:  2006-01       Impact factor: 5.191

2.  Novel hybrid-type antimicrobial agents targeting the switch region of bacterial RNA polymerase.

Authors:  Fumika Yakushiji; Yuko Miyamoto; Yuki Kunoh; Reiko Okamoto; Hidemasa Nakaminami; Yuri Yamazaki; Norihisa Noguchi; Yoshio Hayashi
Journal:  ACS Med Chem Lett       Date:  2013-01-11       Impact factor: 4.345

Review 3.  New target for inhibition of bacterial RNA polymerase: 'switch region'.

Authors:  Aashish Srivastava; Meliza Talaue; Shuang Liu; David Degen; Richard Y Ebright; Elena Sineva; Anirban Chakraborty; Sergey Y Druzhinin; Sujoy Chatterjee; Jayanta Mukhopadhyay; Yon W Ebright; Alex Zozula; Juan Shen; Sonali Sengupta; Rui Rong Niedfeldt; Cai Xin; Takushi Kaneko; Herbert Irschik; Rolf Jansen; Stefano Donadio; Nancy Connell; Richard H Ebright
Journal:  Curr Opin Microbiol       Date:  2011-08-19       Impact factor: 7.934

4.  Structure-based ligand design of novel bacterial RNA polymerase inhibitors.

Authors:  Martin J McPhillie; Rachel Trowbridge; Katherine R Mariner; Alex J O'Neill; A Peter Johnson; Ian Chopra; Colin W G Fishwick
Journal:  ACS Med Chem Lett       Date:  2011-07-29       Impact factor: 4.345

5.  The RNA Polymerase Inhibitor Corallopyronin A Has a Lower Frequency of Resistance Than Rifampicin in Staphylococcus aureus.

Authors:  Jan Balansky; Kenneth Pfarr; Christiane Szekat; Stefan Kehraus; Tilman Aden; Miriam Grosse; Rolf Jansen; Thomas Hesterkamp; Andrea Schiefer; Gabriele M König; Marc Stadler; Achim Hoerauf; Gabriele Bierbaum
Journal:  Antibiotics (Basel)       Date:  2022-07-08

6.  The RNA polymerase "switch region" is a target for inhibitors.

Authors:  Jayanta Mukhopadhyay; Kalyan Das; Sajida Ismail; David Koppstein; Minyoung Jang; Brian Hudson; Stefan Sarafianos; Steven Tuske; Jay Patel; Rolf Jansen; Herbert Irschik; Eddy Arnold; Richard H Ebright
Journal:  Cell       Date:  2008-10-17       Impact factor: 41.582

Review 7.  Structures of RNA polymerase-antibiotic complexes.

Authors:  Mary X Ho; Brian P Hudson; Kalyan Das; Eddy Arnold; Richard H Ebright
Journal:  Curr Opin Struct Biol       Date:  2009-11-18       Impact factor: 6.809

8.  Screening for inhibitors of mutacin synthesis in Streptococcus mutans using fluorescent reporter strains.

Authors:  Priyanka Premnath; Michael Reck; Kathrin Wittstein; Marc Stadler; Irene Wagner-Döbler
Journal:  BMC Microbiol       Date:  2018-03-27       Impact factor: 3.605
  8 in total

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