Literature DB >> 15482926

Aryl urea analogs with broad-spectrum antibacterial activity.

Punit P Seth1, Ray Ranken, Dale E Robinson, Stephen A Osgood, Lisa M Risen, Elizabeth L Rodgers, Michael T Migawa, Elizabeth A Jefferson, Eric E Swayze.   

Abstract

The preparation and evaluation of novel aryl urea analogs as broad-spectrum antibacterial agents is described. Numerous compounds showed low micromolar minimum inhibitory concentrations (MIC) against both Gram-positive and Gram-negative bacteria. Selected analogs also exhibited in vivo efficacy in a lethal murine model of bacterial septicemia.

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Year:  2004        PMID： 15482926     DOI： 10.1016/j.bmcl.2004.08.059

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization.

Authors:  Sayaka Shibata; J Robert Gillespie; Ranae M Ranade; Cho Yeow Koh; Jessica E Kim; Joy U Laydbak; Frank H Zucker; Wim G J Hol; Christophe L M J Verlinde; Frederick S Buckner; Erkang Fan
Journal:  J Med Chem       Date:  2012-07-11       Impact factor: 7.446

2.  Synthesis and Structural Characterization of 1-Arylimidazole-2-thiones and N,N'-Aryldiethoxyethylthioureas with Electronically Diverse Substituents: A Manifold of Hydrogen Bonding Networks.

Authors:  Joshua H Palmer; Gerard Parkin
Journal:  New J Chem       Date:  2014-09-01       Impact factor: 3.591

3.  Crystal structure of 1-(2-amino-phen-yl)-3-phenyl-urea.

Authors:  Joel T Mague; Shaaban K Mohamed; Mehmet Akkurt; Omran A Omran; Mustafa R Albayati
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-01-10

4.  Fe3O4@SiO2 nanoparticle supported ionic liquid for green synthesis of antibacterially active 1-carbamoyl-1-phenylureas in water.

Authors:  Mahmoud Nasrollahzadeh; Zahra Issaabadi; S Mohammad Sajadi
Journal:  RSC Adv       Date:  2018-08-02       Impact factor: 3.361

5.  Design, molecular docking, and molecular dynamics of thiourea-iron (III) metal complexes as NUDT5 inhibitors for breast cancer treatment.

Authors:  Ruswanto Ruswanto; Tita Nofianti; Richa Mardianingrum; Dini Kesuma
Journal:  Heliyon       Date:  2022-09-19
  5 in total

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