| Literature DB >> 15482922 |
Wanjun Zheng1, Boris M Seletsky, Monica H Palme, Paul J Lydon, Lori A Singer, Charles E Chase, Charles A Lemelin, Yongchun Shen, Heather Davis, Lynda Tremblay, Murray J Towle, Kathleen A Salvato, Bruce F Wels, Kimberley K Aalfs, Yoshito Kishi, Bruce A Littlefield, Melvin J Yu.
Abstract
Structurally simplified macrocyclic ketone analogues of halichondrin B were prepared by total synthesis and found to retain the potent cell growth inhibitory activity in vitro, stability in mouse serum, and in vivo efficacy of the natural product.Entities:
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Year: 2004 PMID： 15482922 DOI： 10.1016/j.bmcl.2004.08.069
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823