Literature DB >> 15482904

Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds.

Geoff H Werstuck1, Anna J Kim, Timothy Brenstrum, Stephan A Ohnmacht, Ella Panna, Alfredo Capretta.   

Abstract

A family of compounds based upon the chemical structure of valproate were synthesized and assayed for their ability to inhibit glycogen synthase kinase (GSK)-3 alpha and beta activity in vitro. This data is correlated to the known anti-convulsant properties of these compounds in order to determine the potential role of GSK-3 inhibition in the therapeutic efficacy of these drugs.

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Year:  2004        PMID： 15482904     DOI： 10.1016/j.bmcl.2004.09.013

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

Review 1.  Review of pharmacological treatment in mood disorders and future directions for drug development.

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Journal:  Neuropsychopharmacology       Date:  2011-09-07       Impact factor: 7.853

2.  Protein kinase R-like endoplasmic reticulum kinase and glycogen synthase kinase-3α/β regulate foam cell formation.

Authors:  Cameron S McAlpine; Geoff H Werstuck
Journal:  J Lipid Res       Date:  2014-09-02       Impact factor: 5.922

3.  GSK-3 activity in neocortical cells is inhibited by lithium but not carbamazepine or valproic acid.

Authors:  W Jonathan Ryves; Emma C Dalton; Adrian J Harwood; Robin Sb Williams
Journal:  Bipolar Disord       Date:  2005-06       Impact factor: 6.744

Review 4.  Is glycogen synthase kinase-3 a central modulator in mood regulation?

Authors:  Xiaohua Li; Richard S Jope
Journal:  Neuropsychopharmacology       Date:  2010-07-28       Impact factor: 7.853

Review 5.  GSK-3 is a viable potential target for therapeutic intervention in bipolar disorder.

Authors:  Michael K Rowe; Charlotte Wiest; De-Maw Chuang
Journal:  Neurosci Biobehav Rev       Date:  2007-03-15       Impact factor: 8.989

6.  Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis.

Authors:  Anna J Bowes; Mohammad I Khan; Yuanyuan Shi; Lindsie Robertson; Geoff H Werstuck
Journal:  Am J Pathol       Date:  2008-12-18       Impact factor: 4.307

Review 7.  The role of glucosamine-induced ER stress in diabetic atherogenesis.

Authors:  Daniel R Beriault; Geoff H Werstuck
Journal:  Exp Diabetes Res       Date:  2012-02-23

Review 8.  Role of endoplasmic reticulum stress in atherosclerosis and diabetic macrovascular complications.

Authors:  Dmitry A Chistiakov; Igor A Sobenin; Alexander N Orekhov; Yuri V Bobryshev
Journal:  Biomed Res Int       Date:  2014-07-01       Impact factor: 3.411

9.  The wnt pathway in mood disorders.

Authors:  Gabriele Sani; Flavia Napoletano; Alberto Maria Forte; Giorgio D Kotzalidis; Isabella Panaccione; Giulio Maria Porfiri; Alessio Simonetti; Matteo Caloro; Nicoletta Girardi; Carla Ludovica Telesforo; Giulia Serra; Silvia Romano; Giovanni Manfredi; Valeria Savoja; Stefano Maria Tamorri; Alexia E Koukopoulos; Daniele Serata; Chiara Rapinesi; Antonio Del Casale; Ferdinando Nicoletti; Paolo Girardi
Journal:  Curr Neuropharmacol       Date:  2012-09       Impact factor: 7.363
  9 in total

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