| Literature DB >> 15482786 |
Melissa Kahsar-Miller1, Larry R Boots, Alfred Bartolucci, Ricardo Azziz.
Abstract
We studied 259 consecutive unselected white patients with the polycystic ovary syndrome (PCOS) and 161 matched controls for a common polymorphism of CYP17, the gene encoding for P450c17alpha, and did not observe an important modulatory effect of this variant on circulating DHEAS. It does not appear that this common variant of CYP17, a T to C substitution in the 5' promoter region, plays a significant role in the adrenal androgen excess of PCOS.Entities:
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Year: 2004 PMID： 15482786 DOI： 10.1016/j.fertnstert.2004.05.068
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329