OBJECTIVE: To summarize the existing experience with the use and success rate of assisted reproductive techniques (ART), in particular testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI), in Klinefelter patients. DESIGN: A systematic review of the literature, including all published case reports to date. PATIENT(S): Thirty-nine reported successful pregnancies fathered by nonmosaic Klinefelter patients. MAIN OUTCOME MEASURE(S): The overall risk of transmitting a chromosomal abnormality to the offspring of Klinefelter patients. RESULT(S): In nonmosaic and mosaic Klinefelter patients, chromosomally normal sperm cells can be extracted from testicular tissue and used for ICSI. CONCLUSION(S): The application of ART to Klinefelter patients can be recommended as a method to achieve reproduction in this selected infertility patient cohort.
OBJECTIVE: To summarize the existing experience with the use and success rate of assisted reproductive techniques (ART), in particular testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI), in Klinefelter patients. DESIGN: A systematic review of the literature, including all published case reports to date. PATIENT(S): Thirty-nine reported successful pregnancies fathered by nonmosaic Klinefelter patients. MAIN OUTCOME MEASURE(S): The overall risk of transmitting a chromosomal abnormality to the offspring of Klinefelter patients. RESULT(S): In nonmosaic and mosaic Klinefelter patients, chromosomally normal sperm cells can be extracted from testicular tissue and used for ICSI. CONCLUSION(S): The application of ART to Klinefelter patients can be recommended as a method to achieve reproduction in this selected infertilitypatient cohort.
Authors: F Sciarra; M Pelloni; F Faja; F Pallotti; G Martino; A F Radicioni; A Lenzi; F Lombardo; D Paoli Journal: J Endocrinol Invest Date: 2018-11-29 Impact factor: 4.256
Authors: Merel C Maiburg; Alissia C Hoppenbrouwers; Henk F van Stel; Jacques C Giltay Journal: J Assist Reprod Genet Date: 2011-06-30 Impact factor: 3.412
Authors: Abdulmalik H Almardawi; Rabea Akram; Yara Kattan; Shaheed Saleh Al Suhaibani; Hamed AlAli; Said Kattan; Naif Al Hathal Journal: Urol Ann Date: 2022-01-20