Literature DB >> 1548097

Low biological activity of Helicobacter pylori lipopolysaccharide.

A Muotiala1, I M Helander, L Pyhälä, T U Kosunen, A P Moran.   

Abstract

Lipopolysaccharide from the gastroduodenal pathogen Helicobacter pylori was tested for its ability to induce mitogenicity in mouse spleen cells, pyrogenicity in rabbits, and toxic lethality in galactosamine-sensitized mice. Compared with those for enterobacterial lipopolysaccharide, mitogenicity and pyrogenicity were a thousand-fold lower and lethal toxicity was 500-fold lower. We suggest that the phosphorylation pattern and acylation in lipid A are responsible for the low biological activity.

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Year:  1992        PMID： 1548097      PMCID： PMC257055          DOI： 10.1128/iai.60.4.1714-1716.1992

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  16 in total

1.  Structure-activity relationship of lipid A: comparison of biological activities of natural and synthetic lipid A's with different fatty acid compositions.

Authors:  S Kanegasaki; K Tanamoto; T Yasuda; J Y Homma; M Matsuura; M Nakatsuka; Y Kumazawa; A Yamamoto; T Shiba; S Kusumoto
Journal:  J Biochem       Date:  1986-04       Impact factor: 3.387

2.  Extended deletions in the histidine-rough-B region of the Salmonella chromosome.

Authors:  H Nikaido; M Levinthal; K Nikaido; K Nakane
Journal:  Proc Natl Acad Sci U S A       Date:  1967-06       Impact factor: 11.205

3.  Immunobiologically active lipid A analogs synthesized according to a revised structural model of natural lipid A.

Authors:  S Kotani; H Takada; M Tsujimoto; T Ogawa; K Harada; Y Mori; A Kawasaki; A Tanaka; S Nagao; S Tanaka
Journal:  Infect Immun       Date:  1984-07       Impact factor: 3.441

4.  Endotoxic properties of synthetic pentaacyl lipid A precursor Ib and a structural isomer.

Authors:  E T Rietschel; L Brade; U Schade; C Galanos; M Freudenberg; O Lüderitz; S Kusumoto; T Shiba
Journal:  Eur J Biochem       Date:  1987-11-16

5.  Biological activities of analogues of lipid A based chemically on the revised structural model. Comparison of mediator-inducing, immunomodulating and endotoxic activities.

Authors:  S Kanegasaki; Y Kojima; M Matsuura; J Y Homma; A Yamamoto; Y Kumazawa; K Tanamoto; T Yasuda; T Tsumita; M Imoto
Journal:  Eur J Biochem       Date:  1984-09-03

6.  New Salmonella typhimurium mutants with altered outer membrane permeability.

Authors:  S Sukupolvi; M Vaara; I M Helander; P Viljanen; P H Mäkelä
Journal:  J Bacteriol       Date:  1984-08       Impact factor: 3.490

7.  Galactosamine-induced sensitization to the lethal effects of endotoxin.

Authors:  C Galanos; M A Freudenberg; W Reutter
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

Review 8.  Helicobacter pylori and associated gastroduodenal diseases. Review article.

Authors:  H Rautelin; T U Kosunen
Journal:  APMIS       Date:  1991-08       Impact factor: 3.205

9.  Compositional analysis of Helicobacter pylori rough-form lipopolysaccharides.

Authors:  A P Moran; I M Helander; T U Kosunen
Journal:  J Bacteriol       Date:  1992-02       Impact factor: 3.490

10.  Structural characterization of the lipid A component of Bacteroides fragilis strain NCTC 9343 lipopolysaccharide.

Authors:  A Weintraub; U Zähringer; H W Wollenweber; U Seydel; E T Rietschel
Journal:  Eur J Biochem       Date:  1989-08-01
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  62 in total

1.  Inhibition by 16,16-dimethyl prostaglandin E2 of tumor necrosis factor-alpha and interleukin-1beta production and messenger RNA expression in human monocytes stimulated by Helicobacter pylori.

Authors:  O Takaishi; T Arakawa; Y Fujiwara; T Fukuda; K Otani; K Yamasaki; K Higuchi; T Kuroki
Journal:  Dig Dis Sci       Date:  1999-12       Impact factor: 3.199

Review 2.  Immune response to H. pylori.

Authors:  Giovanni Suarez; Victor E Reyes; Ellen J Beswick
Journal:  World J Gastroenterol       Date:  2006-09-21       Impact factor: 5.742

3.  Implications for induction of autoimmunity via activation of B-1 cells by Helicobacter pylori urease.

Authors:  Shingo Yamanishi; Tadasu Iizumi; Eri Watanabe; Masumi Shimizu; Shigeru Kamiya; Kumiko Nagata; Yoshihiro Kumagai; Yoshitaka Fukunaga; Hidemi Takahashi
Journal:  Infect Immun       Date:  2006-01       Impact factor: 3.441

4.  Rapid development of severe hyperplastic gastritis with gastric epithelial dedifferentiation in Helicobacter felis-infected IL-10(-/-) mice.

Authors:  D J Berg; N A Lynch; R G Lynch; D M Lauricella
Journal:  Am J Pathol       Date:  1998-05       Impact factor: 4.307

Review 5.  Immunopathology of Helicobacter pylori infection and disease.

Authors:  S J Czinn; J G Nedrud
Journal:  Springer Semin Immunopathol       Date:  1997

6.  Reactivities of Lewis antigen monoclonal antibodies with the lipopolysaccharides of Helicobacter pylori strains isolated from patients with gastroduodenal diseases in Japan.

Authors:  K Amano; S Hayashi; T Kubota; N Fujii; S Yokota
Journal:  Clin Diagn Lab Immunol       Date:  1997-09

7.  Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli.

Authors:  Dounia Houamel; Nicolas Ducrot; Thibaud Lefebvre; Raed Daher; Boualem Moulouel; Marie-Agnes Sari; Philippe Letteron; Said Lyoumi; Sarah Millot; Jerome Tourret; Odile Bouvet; Sophie Vaulont; Alain Vandewalle; Erick Denamur; Hervé Puy; Carole Beaumont; Laurent Gouya; Zoubida Karim
Journal:  J Am Soc Nephrol       Date:  2015-08-20       Impact factor: 10.121

Review 8.  Helicobacter pylori persistence: an overview of interactions between H. pylori and host immune defenses.

Authors:  Holly M Scott Algood; Timothy L Cover
Journal:  Clin Microbiol Rev       Date:  2006-10       Impact factor: 26.132

Review 9.  Exploring alternative treatments for Helicobacter pylori infection.

Authors:  Guadalupe Ayala; Wendy Itzel Escobedo-Hinojosa; Carlos Felipe de la Cruz-Herrera; Irma Romero
Journal:  World J Gastroenterol       Date:  2014-02-14       Impact factor: 5.742

10.  Molecular structures that influence the immunomodulatory properties of the lipid A and inner core region oligosaccharides of bacterial lipopolysaccharides.

Authors:  P J Baker; T Hraba; C E Taylor; P W Stashak; M B Fauntleroy; U Zähringer; K Takayama; T R Sievert; X Hronowski; R J Cotter
Journal:  Infect Immun       Date:  1994-06       Impact factor: 3.441
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